A 17-year-old boy with juvenile rheumatoid arthritis presented with jaundice, confusion, hemolytic anemia, thrombocytopenia, and acute renal failure secondary to titer-confirmed acute Epstein-Barr virus (EBV). Renal biopsy specimen revealed interstitial nephritis with an inflammatory infiltrate composed of cytotoxic/suppressor T cells, and interstitial mononuclear cell nuclei expressed EBV encoded RNA-1 (EBER-1) mRNA. Methylprednisolone treatment resulted in rapid improvement.
|Original language||English (US)|
|Number of pages||6|
|Journal||Clinical infectious diseases : an official publication of the Infectious Diseases Society of America|
|State||Published - Dec 2000|
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases