Acute zoster plasma contains elevated amyloid, correlating with Aβ42 and amylin levels, and is amyloidogenic

Andrew N. Bubak, Cheryl Beseler, Christina N. Como, Stephen K. Tyring, Christopher Haley, Teresa Mescher, James E. Hassell, Randall J. Cohrs, Huntington Potter, Maria A. Nagel

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Herpes zoster is associated with an increased dementia and neovascular macular degeneration risk and a decline in glycemic control in diabetes mellitus. Because amyloid is present and pathogenic in these diseases, we quantified amyloid, Aβ40, Aβ42, and amylin in 14 zoster and 10 control plasmas. Compared with controls, zoster plasma had significantly elevated amyloid that correlated with Aβ42 and amylin levels and increased amyloid aggregation with addition of exogenous Aβ42 or amylin. These results suggest that zoster plasma contains factor(s) that promotes aggregation of amyloidogenic peptides, potentially contributing to the toxic amyloid burden and explaining accelerated disease progression following zoster.

Original languageEnglish (US)
Pages (from-to)422-428
Number of pages7
JournalJournal of neurovirology
Volume26
Issue number3
DOIs
StatePublished - Jun 1 2020
Externally publishedYes

Keywords

  • Amylin
  • Amyloid
  • Aβ40
  • Aβ42
  • Herpes zoster
  • Varicella zoster virus

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Virology

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