TY - JOUR
T1 - Adaptive evolution to a high purine and fat diet of carnivorans revealed by gut microbiomes and host genomes
AU - Zhu, Lifeng
AU - Wu, Qi
AU - Deng, Cao
AU - Zhang, Mengjie
AU - Zhang, Chenglin
AU - Chen, Hua
AU - Lu, Guoqing
AU - Wei, Fuwen
N1 - Funding Information:
This work was supported by grants from the National Natural Science Fund for outstanding youth fund (31222009), National Key Programme of Research and Development, Ministry of Science and Technology (2016YFC0503200), National Natural Science Fund (31570489) and the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD). Thanks to Liya Zhou (Nanjing Hongshan Zoo) for help collecting faecal samples.
Publisher Copyright:
© 2018 Society for Applied Microbiology and John Wiley & Sons Ltd
PY - 2018/5
Y1 - 2018/5
N2 - Carnivorous members of the Carnivora reside at the apex of food chains and consume meat-only diets, rich in purine, fats and protein. Here, we aimed to identify potential adaptive evolutionary signatures compatible with high purine and fat metabolism based on analysis of host genomes and symbiotic gut microbial metagenomes. We found that the gut microbiomes of carnivorous Carnivora (e.g., Felidae, Canidae) clustered in the same clade, and other clades comprised omnivorous and herbivorous Carnivora (e.g., badgers, bears and pandas). The relative proportions of genes encoding enzymes involved in uric acid degradation were higher in the gut microbiomes of meat-eating carnivorans than plant-eating species. Adaptive amino acid substitutions in two enzymes, carnitine O-palmitoyltransferase 1 (CPT1A) and lipase F (LIPF), which play a role in fat digestion, were identified in Felidae-Candidae species. Carnivorous carnivorans appear to endure diets high in purines and fats via gut microbiomic and genomic adaptations.
AB - Carnivorous members of the Carnivora reside at the apex of food chains and consume meat-only diets, rich in purine, fats and protein. Here, we aimed to identify potential adaptive evolutionary signatures compatible with high purine and fat metabolism based on analysis of host genomes and symbiotic gut microbial metagenomes. We found that the gut microbiomes of carnivorous Carnivora (e.g., Felidae, Canidae) clustered in the same clade, and other clades comprised omnivorous and herbivorous Carnivora (e.g., badgers, bears and pandas). The relative proportions of genes encoding enzymes involved in uric acid degradation were higher in the gut microbiomes of meat-eating carnivorans than plant-eating species. Adaptive amino acid substitutions in two enzymes, carnitine O-palmitoyltransferase 1 (CPT1A) and lipase F (LIPF), which play a role in fat digestion, were identified in Felidae-Candidae species. Carnivorous carnivorans appear to endure diets high in purines and fats via gut microbiomic and genomic adaptations.
UR - http://www.scopus.com/inward/record.url?scp=85044432765&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85044432765&partnerID=8YFLogxK
U2 - 10.1111/1462-2920.14096
DO - 10.1111/1462-2920.14096
M3 - Article
C2 - 29528548
AN - SCOPUS:85044432765
VL - 20
SP - 1711
EP - 1722
JO - Environmental Microbiology
JF - Environmental Microbiology
SN - 1462-2912
IS - 5
ER -