Adaptive immune regulation of glial homeostasis as an immunization strategy for neurodegenerative diseases

Lisa M. Kosloski, Duy M. Ha, Jessica A.L. Hutter, David K. Stone, Michael R. Pichler, Ashley D. Reynolds, Howard E. Gendelman, R. Lee Mosley

Research output: Contribution to journalReview article

30 Scopus citations

Abstract

Neurodegenerative diseases, notably Alzheimer's and Parkinson's diseases, are amongst the most devastating disorders afflicting the elderly. Currently, no curative treatments or treatments that interdict disease progression exist. Over the past decade, immunization strategies have been proposed to combat disease progression. Such strategies induce humoral immune responses against misfolded protein aggregates to facilitate their clearance. Robust adaptive immunity against misfolded proteins, however, accelerates disease progression, precipitated by induced effector T cell responses that lead to encephalitis and neuronal death. Since then, mechanisms that attenuate such adaptive neurotoxic immune responses have been sought. We propose that shifting the balance between effector and regulatory T cell activity can attenuate neurotoxic inflammatory events. This review summarizes advances in immune regulation to achieve a homeostatic glial response for therapeutic gain. Promising new ways to optimize immunization schemes and measure their clinical efficacy are also discussed.

Original languageEnglish (US)
Pages (from-to)1261-1276
Number of pages16
JournalJournal of Neurochemistry
Volume114
Issue number5
DOIs
StatePublished - Sep 2010

Keywords

  • Parkinson's disease
  • immunization
  • inflammation
  • microglia
  • neuroprotection
  • regulatory T cells
  • therapeutic vaccination

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'Adaptive immune regulation of glial homeostasis as an immunization strategy for neurodegenerative diseases'. Together they form a unique fingerprint.

  • Cite this