Addition of an α-hydroxy acid to the genetic code of bacteria

Jiantao Guo, Jiangyun Wang, J. Christopher Anderson, Peter G. Schultz

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


(Chemical Equation Presented) Playing tag: The α-hydroxy acid p-hydroxy-L-phenyllactic acid has been genetically incorporated into proteins in E. coli in response to an amber nonsense codon. The site-specific introduction of backbone ester mutations was used for the site-specific hydrolysis of an affinity tag, as well as for determination of the energetic contributions of backbone hydrogen bonds to protein stability.

Original languageEnglish (US)
Pages (from-to)722-725
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number4
StatePublished - 2008
Externally publishedYes


  • Backbone mutations
  • Biosynthesis
  • Proteins
  • α-hydroxy acids

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry


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