TY - JOUR
T1 - Adenosine analogs inhibit gastric acid secretion
AU - Westerberg, Verner S.
AU - Geiger, Jonathan D.
N1 - Funding Information:
We wish to thank Dr G Glavm and Mr Grant May for their assistance with some of these experiments This work was supported by grants from the Mamtoba Health Research Council and the Medical Research Council of Canada (MRC) V S Westerberg was a post-doctoral Fellow of the St Boniface General Hospital Research Foundatmn Inc J D Gelger is a Scholar of the MRC
PY - 1989/1/31
Y1 - 1989/1/31
N2 - The potencies with which four adenosine deaminase-resistant analogs of adenosine affected the volume, pH and acid output of basal gastric acid secretions were examined in unanesthetized rats with chronic indwelling gastric cannulas. All four adenosine receptor agonists, R-phenylisopropyladenosine (R-PIA), S-phenylisopropyladenosine (S-PIA), N-ethylcarboxamide adenosine (NECA), and 2-chloroadenosine (CADO) significantly decreased gastric acid output in a dose-dependent manner. The rank order of potency was NECA, R-PIA > CADO > S-PIA. NECA and R-PIA were approximately equipotent in reducing gastric acid output. The levels of gastric acid output tended to increase at the lowest doses of the agonists. NECA decreased the volume of gastric secretion, whereas R-PIA had no effect on volume, but significantly increased the pH of the secretions. Valid measurements of pH in NECA-treated rats were not always obtainable because of near total inhibition of gastric secretions. S-PIA did not significantly affect volume, but increased pH at the higher doses tested. CADO decreased volume, but did not affect pH. These results indicate that adenosine analogs regulate not only the hydrogen ion concentration, but also the volume of gastric secretions.
AB - The potencies with which four adenosine deaminase-resistant analogs of adenosine affected the volume, pH and acid output of basal gastric acid secretions were examined in unanesthetized rats with chronic indwelling gastric cannulas. All four adenosine receptor agonists, R-phenylisopropyladenosine (R-PIA), S-phenylisopropyladenosine (S-PIA), N-ethylcarboxamide adenosine (NECA), and 2-chloroadenosine (CADO) significantly decreased gastric acid output in a dose-dependent manner. The rank order of potency was NECA, R-PIA > CADO > S-PIA. NECA and R-PIA were approximately equipotent in reducing gastric acid output. The levels of gastric acid output tended to increase at the lowest doses of the agonists. NECA decreased the volume of gastric secretion, whereas R-PIA had no effect on volume, but significantly increased the pH of the secretions. Valid measurements of pH in NECA-treated rats were not always obtainable because of near total inhibition of gastric secretions. S-PIA did not significantly affect volume, but increased pH at the higher doses tested. CADO decreased volume, but did not affect pH. These results indicate that adenosine analogs regulate not only the hydrogen ion concentration, but also the volume of gastric secretions.
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U2 - 10.1016/0014-2999(89)90500-1
DO - 10.1016/0014-2999(89)90500-1
M3 - Article
C2 - 2759171
AN - SCOPUS:0024546610
SN - 0014-2999
VL - 160
SP - 275
EP - 281
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 2
ER -