Adenosine Receptors and Memory Disorders

Alexandre de Mendonca, David Blum, Jonathan D. Geiger

Research output: Chapter in Book/Report/Conference proceedingChapter


Alzheimer's disease (AD) is the most prevalent form of dementia in the aged population. Definitive diagnosis of AD is based on the presence of senile plaques and neurofibrillary tangles that are identified in postmortem brain specimens. The formation of AD specific lesions is attributed to the pathological accumulation of either extracellular amyloid beta (A) peptide or intraneuronal hyperphosphorylated Tau protein. Constituents of the lesions are prone to promoting synaptic deficits, leading to memory impairments. However, besides targeting lesions, other pathways maybe of interest to control, such as inflammatory processes. Epidemiological studies report beneficial effects of caffeine, a nonselective antagonist of adenosine receptors. In the present review, we discuss the impact of caffeine and the adenosinergic system in AD pathology as well as consequences in terms of pathology and therapeutics.

Original languageEnglish (US)
Title of host publicationAdenosine Receptors in Neurodegenerative Diseases
PublisherElsevier Inc.
Number of pages12
ISBN (Electronic)9780128037454
ISBN (Print)9780128037249
StatePublished - Mar 30 2017
Externally publishedYes


  • Adenosine
  • Adenosine receptors
  • Alzheimer's disease
  • Caffeine
  • Memory

ASJC Scopus subject areas

  • General Medicine
  • General Neuroscience


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