Adenosine Receptors and Memory Disorders

Alexandre de Mendonca; David Blum; Jonathan D. Geiger

doi:10.1016/B978-0-12-803724-9.00009-0

Adenosine Receptors and Memory Disorders

Alexandre de Mendonca, David Blum, Jonathan D. Geiger

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Alzheimer's disease (AD) is the most prevalent form of dementia in the aged population. Definitive diagnosis of AD is based on the presence of senile plaques and neurofibrillary tangles that are identified in postmortem brain specimens. The formation of AD specific lesions is attributed to the pathological accumulation of either extracellular amyloid beta (A) peptide or intraneuronal hyperphosphorylated Tau protein. Constituents of the lesions are prone to promoting synaptic deficits, leading to memory impairments. However, besides targeting lesions, other pathways maybe of interest to control, such as inflammatory processes. Epidemiological studies report beneficial effects of caffeine, a nonselective antagonist of adenosine receptors. In the present review, we discuss the impact of caffeine and the adenosinergic system in AD pathology as well as consequences in terms of pathology and therapeutics.

Original language	English (US)
Title of host publication	Adenosine Receptors in Neurodegenerative Diseases
Publisher	Elsevier Inc.
Pages	175-186
Number of pages	12
ISBN (Electronic)	9780128037454
ISBN (Print)	9780128037249
DOIs	https://doi.org/10.1016/B978-0-12-803724-9.00009-0
State	Published - Mar 30 2017
Externally published	Yes

Keywords

Adenosine
Adenosine receptors
Alzheimer's disease
Caffeine
Memory

ASJC Scopus subject areas

Medicine(all)
Neuroscience(all)

Access to Document

10.1016/B978-0-12-803724-9.00009-0

Cite this

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abstract = "Alzheimer's disease (AD) is the most prevalent form of dementia in the aged population. Definitive diagnosis of AD is based on the presence of senile plaques and neurofibrillary tangles that are identified in postmortem brain specimens. The formation of AD specific lesions is attributed to the pathological accumulation of either extracellular amyloid beta (A) peptide or intraneuronal hyperphosphorylated Tau protein. Constituents of the lesions are prone to promoting synaptic deficits, leading to memory impairments. However, besides targeting lesions, other pathways maybe of interest to control, such as inflammatory processes. Epidemiological studies report beneficial effects of caffeine, a nonselective antagonist of adenosine receptors. In the present review, we discuss the impact of caffeine and the adenosinergic system in AD pathology as well as consequences in terms of pathology and therapeutics.",

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AU - Blum, David

AU - Geiger, Jonathan D.

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AB - Alzheimer's disease (AD) is the most prevalent form of dementia in the aged population. Definitive diagnosis of AD is based on the presence of senile plaques and neurofibrillary tangles that are identified in postmortem brain specimens. The formation of AD specific lesions is attributed to the pathological accumulation of either extracellular amyloid beta (A) peptide or intraneuronal hyperphosphorylated Tau protein. Constituents of the lesions are prone to promoting synaptic deficits, leading to memory impairments. However, besides targeting lesions, other pathways maybe of interest to control, such as inflammatory processes. Epidemiological studies report beneficial effects of caffeine, a nonselective antagonist of adenosine receptors. In the present review, we discuss the impact of caffeine and the adenosinergic system in AD pathology as well as consequences in terms of pathology and therapeutics.

KW - Adenosine

KW - Adenosine receptors

KW - Alzheimer's disease

KW - Caffeine

KW - Memory

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ER -

Adenosine Receptors and Memory Disorders

Abstract

Keywords

ASJC Scopus subject areas

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