Adenovirus infections in heart transplantation

Diana F. Florescu, Joong Y. Kwon, Ioana Dumitru

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

Adenovirus infections have been associated with significant morbidity and mortality in immunocompromised hosts. The clinical significance of adenovirus disease in heart transplantation is not well-defined; in particular, the significance of adenovirus identification in myocardium remains unclear. Although severe adenovirus disease has been described in heart transplant recipients, adenovirus infections seem to be more frequently associated with increased risk of adverse cardiac events, such as rejection, ventricular dysfunction, coronary vasculopathy, need for retransplantation, and graft loss because of death. Cidofovir is currently considered the standard of treatment for adenovirus disease not responding to reduction of immunosuppression.

Original languageEnglish (US)
Pages (from-to)203-206
Number of pages4
JournalCardiology in review
Volume21
Issue number4
DOIs
StatePublished - Jul 2013

Keywords

  • adenovirus disease
  • adenovirus infection
  • heart transplant

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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