Adjunctive Rifampin Following Debridement and Implant Retention for Staphylococcal Prosthetic Joint Infection: Is it Effective if not Combined With a Fluoroquinolone?

Nicolás W. Cortés-Penfield; Angela L. Hewlett; Andre C. Kalil

doi:10.1093/ofid/ofac582

Adjunctive Rifampin Following Debridement and Implant Retention for Staphylococcal Prosthetic Joint Infection: Is it Effective if not Combined With a Fluoroquinolone?

Nicolás W. Cortés-Penfield, Angela L. Hewlett, Andre C. Kalil

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Whether rifampin benefits retained staphylococcal prosthetic joint infection is unsettled. In a meta-analysis of 8 studies, we found greater clinical cure with fluoroquinolone-rifampin vs all other regimens (odds ratio [OR], 2.68; 95% CI, 1.43-5.02), but no greater cure with other rifampin combinations vs regimens without rifampin (OR, 1.22; 95% CI, 0.79-1.88).

Original language	English (US)
Article number	ofac582
Journal	Open Forum Infectious Diseases
Volume	9
Issue number	12
DOIs	https://doi.org/10.1093/ofid/ofac582
State	Published - Dec 1 2022

Keywords

Prosthetic joint infection
fluoroquinolone
rifampin
staphylococcus

ASJC Scopus subject areas

Oncology
Infectious Diseases

Access to Document

10.1093/ofid/ofac582

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Adjunctive Rifampin Following Debridement and Implant Retention for Staphylococcal Prosthetic Joint Infection: Is it Effective if not Combined With a Fluoroquinolone? / Cortés-Penfield, Nicolás W.; Hewlett, Angela L.; Kalil, Andre C.
In: Open Forum Infectious Diseases, Vol. 9, No. 12, ofac582, 01.12.2022.

Research output: Contribution to journal › Article › peer-review

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abstract = "Whether rifampin benefits retained staphylococcal prosthetic joint infection is unsettled. In a meta-analysis of 8 studies, we found greater clinical cure with fluoroquinolone-rifampin vs all other regimens (odds ratio [OR], 2.68; 95% CI, 1.43-5.02), but no greater cure with other rifampin combinations vs regimens without rifampin (OR, 1.22; 95% CI, 0.79-1.88).",

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Adjunctive Rifampin Following Debridement and Implant Retention for Staphylococcal Prosthetic Joint Infection: Is it Effective if not Combined With a Fluoroquinolone?

Abstract

Keywords

ASJC Scopus subject areas

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