TY - JOUR
T1 - Administration of clozapine to a mother rat potentiates pup ultrasonic vocalization in response to separation and re-separation
T2 - Contrast with haloperidol
AU - Li, Ming
AU - He, Wei
AU - Heupel, Katherine
N1 - Funding Information:
This research was supported by a grant from the National Institute of Mental Health ( 5R03MH080822-02 ) to Dr. Ming Li. We would like to thank the Undergraduate Creative Activities and Research Experience program for funding support for Katherine Heupel.
PY - 2011/9/23
Y1 - 2011/9/23
N2 - The present study examined how haloperidol (typical) and clozapine (atypical) treatment to mother rats affected their pups' ultrasonic vocalization (USV) response to maternal separation and re-separation (termed " maternal potentiation" ). Clozapine (10. mg/kg, sc) but not haloperidol (0.2. mg/kg, sc) significantly enhanced the maternal potentiation of 40. kHz USVs in pups that were briefly reunited with their dams. This novel paradigm provides an indirect way of assessing the impact of antipsychotic treatment on the quality of maternal care. It may also be useful in examining the impact of antipsychotic treatment on social bonding between infants and mothers.
AB - The present study examined how haloperidol (typical) and clozapine (atypical) treatment to mother rats affected their pups' ultrasonic vocalization (USV) response to maternal separation and re-separation (termed " maternal potentiation" ). Clozapine (10. mg/kg, sc) but not haloperidol (0.2. mg/kg, sc) significantly enhanced the maternal potentiation of 40. kHz USVs in pups that were briefly reunited with their dams. This novel paradigm provides an indirect way of assessing the impact of antipsychotic treatment on the quality of maternal care. It may also be useful in examining the impact of antipsychotic treatment on social bonding between infants and mothers.
KW - Maternal behavior
KW - Maternal potentiation of pup vocalization
KW - Maternal separation
KW - Pup ultrasonic vocalization
KW - Rat
UR - http://www.scopus.com/inward/record.url?scp=79955949007&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79955949007&partnerID=8YFLogxK
U2 - 10.1016/j.bbr.2011.03.062
DO - 10.1016/j.bbr.2011.03.062
M3 - Article
C2 - 21473887
AN - SCOPUS:79955949007
SN - 0166-4328
VL - 222
SP - 385
EP - 389
JO - Behavioural Brain Research
JF - Behavioural Brain Research
IS - 2
ER -