Adolescent opioid abuse: Role of glial and neuroimmune mechanisms

S. Rahman, Z. I. Rahman, P. J. Ronan, K. Lutfy, R. L. Bell

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Opioids are widely prescribed for pain management, and prescription opioid misuse in adolescents has become a major epidemic in the United States and worldwide. Emerging data indicate that adolescence represents a critical period of brain development, and exposure to opioids during adolescence may increase the risk of addiction in adulthood. There is growing evidence that disruptions in brain glial function may be implicated in numerous chronic neuropathologies. Evidence suggests that glial mechanisms have an important role in the development and maintenance of opioid abuse and the risk for addiction. This review will describe glial and neuroimmune mechanisms involved in opioid use disorders during adolescence, which may increase substance use disorder liability later in life. Moreover, this review will identify some important neuro-glial targets, involved in opioid abuse and addiction, to develop future preventions and treatment strategies.

Original languageEnglish (US)
Title of host publicationEffects of Peri-Adolescent Licit and Illicit Drug Use on the Developing CNS Part II
EditorsRichard L. Bell, Shafiqur Rahman
PublisherAcademic Press Inc.
Pages147-165
Number of pages19
ISBN (Print)9780323992602
DOIs
StatePublished - Jan 2022
Externally publishedYes

Publication series

NameInternational Review of Neurobiology
Volume161
ISSN (Print)0074-7742
ISSN (Electronic)2162-5514

Keywords

  • Adolescence
  • Astrocyte
  • Drug addiction
  • Glia
  • Microglia
  • Neuroimmune mechanism
  • Neuroinflammation
  • Opioid addiction
  • Opioid use disorders

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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