Adrenoleukodystrophy: Oleic acid lowers fibroblast saturated C22–26 fatty acids

William B. Rizzo, Paul A. Watkins, Mary W. Phillips, Debra Cranin, Brian Campbell, Joel Avigan

Research output: Contribution to journalArticle

102 Scopus citations

Abstract

Monounsaturated fatty acids, especially oleic acid (C18:1), decreased the content of saturated very-long-chain fatty acids (VLFA) in cultured skin fibroblasts from patients with adrenoleukodystrophy (ALD) and controls. When confluent ALD fibroblasts were incubated with oleic acid for 5 days in lipid-free medium, which eliminates uptake of exogenous VLFA, the mean cell content of C26:0 was decreased by 33.7 ± 10.1%. Oleic acid inhibited C26:0 synthesis in ALD fibroblasts by 58% and total fatty acid synthesis by 68 to 78%. Therefore, the elevated C26:0 levels in ALD cells may be lowered by inhibiting fatty acid biosynthesis, and inhibition of saturated VLFA synthesis by oleate may be useful in treating ALD.

Original languageEnglish (US)
Pages (from-to)357-361
Number of pages5
JournalNeurology
Volume36
Issue number3
DOIs
StatePublished - Mar 1986

ASJC Scopus subject areas

  • Clinical Neurology

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    Rizzo, W. B., Watkins, P. A., Phillips, M. W., Cranin, D., Campbell, B., & Avigan, J. (1986). Adrenoleukodystrophy: Oleic acid lowers fibroblast saturated C22–26 fatty acids. Neurology, 36(3), 357-361. https://doi.org/10.1212/wnl.36.3.357