TY - JOUR
T1 - Advanced preparation makes research in emergencies and isolation care possible
T2 - The case of novel coronavirus disease (CoVID-19)
AU - Brett-Major, David M.
AU - Schnaubelt, Elizabeth R.
AU - Creager, Hannah M.
AU - Lowe, Abigail
AU - Cieslak, Theodore J.
AU - Dahlke, Jacob M.
AU - Johnson, Daniel W.
AU - Fey, Paul D.
AU - Hansen, Keith F.
AU - Hewlett, Angela L.
AU - Gordon, Bruce G.
AU - Kalil, Andre C.
AU - Khan, Ali S.
AU - Kortepeter, Mark G.
AU - Kratochvil, Christopher J.
AU - Larson, Lu Ann
AU - Levy, Deborah A.
AU - Linder, James
AU - Medcalf, Sharon J.
AU - Rupp, Mark E.
AU - Schwedhelm, Michelle M.
AU - Sullivan, James
AU - Vasa, Angela M.
AU - Wadman, Michael C.
AU - Lookadoo, Rachel E.
AU - Lowe, John Martin J.
AU - Lawler, James V.
AU - Jana Broadhurst, M.
N1 - Funding Information:
Acknowledgments: We thank our patients; our clinical and administrative staff; emergency medical services; public health officials at county, state, and federal levels; and many others for their important contributions to daily work and care of delivered patients, without which this research would be impossible. UNMC/NM nursing is superb and important to application of study procedures. Shahnaz Benner conducted phlebotomy in isolation care, and Morgan Shradar conducted swab sampling. Teresa Hartman and Sara Donovan assisted in developing the Critical Questions and Ethics committee reference library. This article describes the creation and management of UNMC/NM IRB-approved protocol no. 146-20-FB, UNMC/NM Clinical characterization protocol for severe emerging infections. This study is currently operated on institutional funding only, although HHS support of quarantine and isolation efforts is received. The NIAID RCT for remdesivir also is running at UNMC/NM with IRB approval and extramural support. Views expressed are those of the authors and not necessarily those of the State of Nebraska, the U.S. government, or any of their agencies. Publication charges for this article were waived due to the ongoing pandemic of COVID-19.
Publisher Copyright:
© 2020 by The American Society of Tropical Medicine and Hygiene
PY - 2020
Y1 - 2020
N2 - The optimal time to initiate research on emergencies is before they occur. However, timely initiation of high-quality research may launch during an emergency under the right conditions. These include an appropriate context, clarity in scientific aims, preexisting resources, strong operational and research structures that are facile, and good governance. Here, Nebraskan rapid research efforts early during the 2020 coronavirus disease pandemic, while participating in the first use of U.S. federal quarantine in 50 years, are described from these aspects, as the global experience with this severe emerging infection grew apace. The experience has lessons in purpose, structure, function, and performance of research in any emergency, when facing any threat.
AB - The optimal time to initiate research on emergencies is before they occur. However, timely initiation of high-quality research may launch during an emergency under the right conditions. These include an appropriate context, clarity in scientific aims, preexisting resources, strong operational and research structures that are facile, and good governance. Here, Nebraskan rapid research efforts early during the 2020 coronavirus disease pandemic, while participating in the first use of U.S. federal quarantine in 50 years, are described from these aspects, as the global experience with this severe emerging infection grew apace. The experience has lessons in purpose, structure, function, and performance of research in any emergency, when facing any threat.
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U2 - 10.4269/AJTMH.20-0205
DO - 10.4269/AJTMH.20-0205
M3 - Review article
C2 - 32228780
AN - SCOPUS:85084570474
SN - 0002-9637
VL - 102
SP - 926
EP - 931
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
IS - 5
ER -