Advances and challenges in understanding endosomal sorting and fission

Naava Naslavsky; Steve Caplan

doi:10.1111/febs.16687

Advances and challenges in understanding endosomal sorting and fission

Research output: Contribution to journal › Article › peer-review

Abstract

Endosomes play crucial roles in the cell, serving as focal and ‘triage’ points for internalized lipids and receptors. As such, endosomes are a critical branching point that determines whether receptors are sorted for degradation or recycling. This Viewpoint aims to highlight recent advances in endosome research, including key endosomal functions such as sorting and fission. Moreover, the Viewpoint addresses key technical and conceptual challenges in studying endosomes.

Original language	English (US)
Journal	FEBS Journal
DOIs	https://doi.org/10.1111/febs.16687
State	Accepted/In press - 2022

Keywords

actin
early endosome
EHD1
fission
late endosome
RAB
recycling endosome
sorting endosome
trafficking

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1111/febs.16687

Cite this

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title = "Advances and challenges in understanding endosomal sorting and fission",

abstract = "Endosomes play crucial roles in the cell, serving as focal and {\textquoteleft}triage{\textquoteright} points for internalized lipids and receptors. As such, endosomes are a critical branching point that determines whether receptors are sorted for degradation or recycling. This Viewpoint aims to highlight recent advances in endosome research, including key endosomal functions such as sorting and fission. Moreover, the Viewpoint addresses key technical and conceptual challenges in studying endosomes.",

keywords = "actin, early endosome, EHD1, fission, late endosome, RAB, recycling endosome, sorting endosome, trafficking",

author = "Naava Naslavsky and Steve Caplan",

note = "Funding Information: This work was supported by NIH grant R35GM144102 from the National Institute of General Medical Sciences (SC). Publisher Copyright: {\textcopyright} 2022 Federation of European Biochemical Societies.",

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AU - Caplan, Steve

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PY - 2022

Y1 - 2022

N2 - Endosomes play crucial roles in the cell, serving as focal and ‘triage’ points for internalized lipids and receptors. As such, endosomes are a critical branching point that determines whether receptors are sorted for degradation or recycling. This Viewpoint aims to highlight recent advances in endosome research, including key endosomal functions such as sorting and fission. Moreover, the Viewpoint addresses key technical and conceptual challenges in studying endosomes.

AB - Endosomes play crucial roles in the cell, serving as focal and ‘triage’ points for internalized lipids and receptors. As such, endosomes are a critical branching point that determines whether receptors are sorted for degradation or recycling. This Viewpoint aims to highlight recent advances in endosome research, including key endosomal functions such as sorting and fission. Moreover, the Viewpoint addresses key technical and conceptual challenges in studying endosomes.

KW - actin

KW - early endosome

KW - EHD1

KW - fission

KW - late endosome

KW - RAB

KW - recycling endosome

KW - sorting endosome

KW - trafficking

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Advances and challenges in understanding endosomal sorting and fission

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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