@article{f551cf8369464a6093b4ac7a8a6ccda7,
title = "Age and Sex Influence Mitochondria and Cardiac Health in Offspring Exposed to Maternal Glucolipotoxicity",
abstract = "Biological",
keywords = "Animal Physiology, Biological Sciences, Cell Biology, Diabetology, Molecular Biology, Physiology",
author = "Louwagie, {Eli J.} and Larsen, {Tricia D.} and Wachal, {Angela L.} and Gandy, {Tyler C.T.} and Eclov, {Julie A.} and Rideout, {Todd C.} and Kern, {Katherine A.} and Cain, {Jacob T.} and Anderson, {Ruthellen H.} and Mdaki, {Kennedy S.} and Baack, {Michelle L.}",
note = "Funding Information: Authors thank the Sanford Histology and Imaging Core and Claire Evans and Kelly Graber for invaluable assistance with staining and confocal microscopy. We also thank the Sanford Animal Research Center, particularly Jennifer Agar, Kelsey Bush, and Brandon Whipple, for their skilled care and dedication to animal welfare. The study was supported by the National Institute of Children's Health and Disease ( NIH -NICHD K08 HD078504 ), the Sanford Center for Pediatric Research (NIH-NIGMS CoBRE 2P20GM103620-06 ), the Sanford Center for Cancer Biology Research (NIH-NIGMS CoBRE P20GM103548 ), the National Center for Complementary and Integrative Health (NIH-NCCIH 1K01AT007826-01A1 ), and a National Science Foundation Sanford Program for Undergraduate Research (SPUR) training grant (NSF REU DBI-1262744 ). Funding Information: Authors thank the Sanford Histology and Imaging Core and Claire Evans and Kelly Graber for invaluable assistance with staining and confocal microscopy. We also thank the Sanford Animal Research Center, particularly Jennifer Agar, Kelsey Bush, and Brandon Whipple, for their skilled care and dedication to animal welfare. The study was supported by the National Institute of Children's Health and Disease (NIH-NICHD K08 HD078504), the Sanford Center for Pediatric Research (NIH-NIGMS CoBRE 2P20GM103620-06), the Sanford Center for Cancer Biology Research (NIH-NIGMS CoBRE P20GM103548), the National Center for Complementary and Integrative Health (NIH-NCCIH 1K01AT007826-01A1), and a National Science Foundation Sanford Program for Undergraduate Research (SPUR) training grant (NSF REU DBI-1262744). M.L.B. is the principal investigator who conceived the study and with K.S.M. and E.J.L. developed methods. M.L.B. and E.J.L. designed and validated experiments, analyzed the data, and wrote the manuscript. E.J.L. T.D.L. T.C.T.G. and J.A.E. performed animal work, cardiomyocyte isolation, seahorse XF analyses, and serum and protein analyses. T.D.L acquired echocardiography, which was analyzed by A.L.W. K.S.M. R.H.A. and J.T.C. helped develop, optimize, and validate imaging assays and HCS analyses methods. T.C.R. and K.A.K. performed maternal and offspring serum and liver lipid profiling. All authors assisted in experiments and contributed to development and review of this manuscript. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2020 The Author(s)",
year = "2020",
month = nov,
day = "20",
doi = "10.1016/j.isci.2020.101746",
language = "English (US)",
volume = "23",
journal = "iScience",
issn = "2589-0042",
publisher = "Elsevier Inc.",
number = "11",
}