Age-related alterations in the morphology of femoral artery vasa vasorum in the rat

Gregg D. Phillips; A. Marika Stone; Julie C. Schultz; Russell A. Whitehead; Bryan D. Jones; Margot L. Goodkin; Mark W. Ruebel; David R. Knighton

doi:10.1016/0047-6374(95)01604-X

Age-related alterations in the morphology of femoral artery vasa vasorum in the rat

Gregg D. Phillips, A. Marika Stone, Julie C. Schultz, Russell A. Whitehead, Bryan D. Jones, Margot L. Goodkin, Mark W. Ruebel, David R. Knighton

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The objective of this study was to explore any age-related morphological changes in the vasa vasorum of the rat femoral artery. Vascular corrosion casts were prepared from 2, 12 and 24-month-old rats. Examination of the casts with the scanning electron microscope revealed dramatic differences in the appearance of the vessels of young and aged rats. The vasa vasorum of 2-month-old rats consisted of a dense network of capillaries. These vessels were dramatically reduced in number by 12 months, and even fewer capillaries were present at 24 months. This reduction in capillary density is consistent with the observed age-related decreases in oxygen tension and may explain why the aged are more prone to atherosclerosis.

Original language	English (US)
Pages (from-to)	149-154
Number of pages	6
Journal	Mechanisms of Ageing and Development
Volume	82
Issue number	2-3
DOIs	https://doi.org/10.1016/0047-6374(95)01604-X
State	Published - Aug 8 1995
Externally published	Yes

Keywords

Aging
Atherosclerosis
Femoral artery
Scanning electron microscopy
Vasa vasorum
Vascular corrosion casts

ASJC Scopus subject areas

Aging
Developmental Biology

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10.1016/0047-6374(95)01604-X

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title = "Age-related alterations in the morphology of femoral artery vasa vasorum in the rat",

abstract = "The objective of this study was to explore any age-related morphological changes in the vasa vasorum of the rat femoral artery. Vascular corrosion casts were prepared from 2, 12 and 24-month-old rats. Examination of the casts with the scanning electron microscope revealed dramatic differences in the appearance of the vessels of young and aged rats. The vasa vasorum of 2-month-old rats consisted of a dense network of capillaries. These vessels were dramatically reduced in number by 12 months, and even fewer capillaries were present at 24 months. This reduction in capillary density is consistent with the observed age-related decreases in oxygen tension and may explain why the aged are more prone to atherosclerosis.",

keywords = "Aging, Atherosclerosis, Femoral artery, Scanning electron microscopy, Vasa vasorum, Vascular corrosion casts",

author = "Phillips, {Gregg D.} and {Marika Stone}, A. and Schultz, {Julie C.} and Whitehead, {Russell A.} and Jones, {Bryan D.} and Goodkin, {Margot L.} and Ruebel, {Mark W.} and Knighton, {David R.}",

note = "Funding Information: This work was supportedb y an NIH ShannonA ward (R55 GM48158)t o G.D. Phillips, a W.M. Keck FoundationG rant (921268g) rantedt o MacalesterC ollegei n 1992,a nd an NSF Grant (CSI-8552182).",

year = "1995",

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day = "8",

doi = "10.1016/0047-6374(95)01604-X",

language = "English (US)",

volume = "82",

pages = "149--154",

journal = "Mechanisms of Ageing and Development",

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T1 - Age-related alterations in the morphology of femoral artery vasa vasorum in the rat

AU - Phillips, Gregg D.

AU - Marika Stone, A.

AU - Schultz, Julie C.

AU - Whitehead, Russell A.

AU - Jones, Bryan D.

AU - Goodkin, Margot L.

AU - Ruebel, Mark W.

AU - Knighton, David R.

N1 - Funding Information: This work was supportedb y an NIH ShannonA ward (R55 GM48158)t o G.D. Phillips, a W.M. Keck FoundationG rant (921268g) rantedt o MacalesterC ollegei n 1992,a nd an NSF Grant (CSI-8552182).

PY - 1995/8/8

Y1 - 1995/8/8

N2 - The objective of this study was to explore any age-related morphological changes in the vasa vasorum of the rat femoral artery. Vascular corrosion casts were prepared from 2, 12 and 24-month-old rats. Examination of the casts with the scanning electron microscope revealed dramatic differences in the appearance of the vessels of young and aged rats. The vasa vasorum of 2-month-old rats consisted of a dense network of capillaries. These vessels were dramatically reduced in number by 12 months, and even fewer capillaries were present at 24 months. This reduction in capillary density is consistent with the observed age-related decreases in oxygen tension and may explain why the aged are more prone to atherosclerosis.

AB - The objective of this study was to explore any age-related morphological changes in the vasa vasorum of the rat femoral artery. Vascular corrosion casts were prepared from 2, 12 and 24-month-old rats. Examination of the casts with the scanning electron microscope revealed dramatic differences in the appearance of the vessels of young and aged rats. The vasa vasorum of 2-month-old rats consisted of a dense network of capillaries. These vessels were dramatically reduced in number by 12 months, and even fewer capillaries were present at 24 months. This reduction in capillary density is consistent with the observed age-related decreases in oxygen tension and may explain why the aged are more prone to atherosclerosis.

KW - Aging

KW - Atherosclerosis

KW - Femoral artery

KW - Scanning electron microscopy

KW - Vasa vasorum

KW - Vascular corrosion casts

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IS - 2-3

ER -

Age-related alterations in the morphology of femoral artery vasa vasorum in the rat

Abstract

Keywords

ASJC Scopus subject areas

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