Aging, immunity and neuroendocrine hormones

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Recent evidence indicates that the neuroendocrine and immune systems are intimately integrated into one system that provides a complex homeostatic network. Disruption of one system by extrinsic factors such as stress or antigenic exposure usually has consequences on the other. With advancing age, a progressive disruption can be observed in both systems which may have profound implications with respect to age-associated pathologies, including autoimmunity. In this review evidence is summarized which supports the hypothesis that neuroendocrine factors influence the age-associated decline of the immune system.

Original languageEnglish (US)
Pages (from-to)419-432
Number of pages14
JournalAdvances in Neuroimmunology
Issue number4
StatePublished - 1996
Externally publishedYes


  • Aging
  • gerontology
  • immune system
  • neuroendocrine system
  • neuroimmunomodulation

ASJC Scopus subject areas

  • General Neuroscience
  • Immunology


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