Abstract
Recent evidence indicates that the neuroendocrine and immune systems are intimately integrated into one system that provides a complex homeostatic network. Disruption of one system by extrinsic factors such as stress or antigenic exposure usually has consequences on the other. With advancing age, a progressive disruption can be observed in both systems which may have profound implications with respect to age-associated pathologies, including autoimmunity. In this review evidence is summarized which supports the hypothesis that neuroendocrine factors influence the age-associated decline of the immune system.
Original language | English (US) |
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Pages (from-to) | 419-432 |
Number of pages | 14 |
Journal | Advances in Neuroimmunology |
Volume | 6 |
Issue number | 4 |
DOIs | |
State | Published - 1996 |
Externally published | Yes |
Keywords
- Aging
- gerontology
- immune system
- neuroendocrine system
- neuroimmunomodulation
ASJC Scopus subject areas
- General Neuroscience
- Immunology