Aging-related changes in extracellular matrix: Implications for ventricular remodeling following myocardial infarction

Nguyen T. Nguyen, Andriy Yabluchanskiy, Lisandra E. De Castro Brás, Yu Fang Jin, Merry L. Lindsey

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

In humans, age-related changes in the myocardium include increases in vascular intimal thickness, vascular stiffness, left ventricle (LV) wall thickness, and left atrial size. These changes in tissue structure and function are the result of altered expression profiles of extracellular matrix (ECM) components. While aging itself is not a pathological condition, this resetting of homeostasis sets up the LV to respond poorly to stress. As a reflection of this, morbidity and mortality rates after myocardial infarction (MI) strongly correlate with advancing age. To date, targeting specific ECM components for therapeutic purposes has only been achieved by indirect mechanisms. This book chapter summarizes the current knowledge of ECM remodeling during aging and MI, focusing on mechanistic insights that may reveal avenues to explore for therapeutic potential.

Original languageEnglish (US)
Title of host publicationAging and Heart Failure
Subtitle of host publicationMechanisms and Management
PublisherSpringer New York
Pages377-389
Number of pages13
ISBN (Electronic)9781493902682
ISBN (Print)9781493902675
DOIs
StatePublished - Jan 1 2014

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Aging-related changes in extracellular matrix: Implications for ventricular remodeling following myocardial infarction'. Together they form a unique fingerprint.

  • Cite this

    Nguyen, N. T., Yabluchanskiy, A., De Castro Brás, L. E., Jin, Y. F., & Lindsey, M. L. (2014). Aging-related changes in extracellular matrix: Implications for ventricular remodeling following myocardial infarction. In Aging and Heart Failure: Mechanisms and Management (pp. 377-389). Springer New York. https://doi.org/10.1007/9781493902682