Abstract
We studied the characteristics and temporal trends of AIDS-associated non-Hodgkin's lymphoma (AIDS-NHL) in individuals with hemophilia. Prospective data were collected on 33 HIV-positive hemophiliacs with AIDS-NHL enrolled in the Hemophilia Malignancy Study (HMS), of whom 21 had primary and 12 had secondary or subsequent AIDS-defining illnesses, and analyzed for frequency and temporal trends. As compared with primary AIDS-NHL, secondary AIDS-NHL occurred at an older mean age, 37 versus 29 years (p =0.12); at a lower mean CD4 count, 46 versus 154 (p = 0.07); after a longer period of immunosuppression (CD4 < 200/μl), 41 versus 16 months (p = 0.03); and with shorter median survival, 2 versus 7 months (p = 0.09). The presence of EBV in tumor tissue was associated with shorter survival, 1 versus 7 months (p = 0.17). Between 1981 and 1988 and 1989 and 1994, the proportion of primary AIDS diagnoses that were AIDS-NHL changed minimally, 4.6 versus 6.1%, whereas there were significant decreases in Pneumocystis carinii pneumonia (PCP, p = 0.02) and wasting (p = 0.07), and an increase in Candida (p = 0.004). These findings confirm that an increasing proportion of AIDS-NHL in hemophiliacs are occurring as secondary or later AIDS diagnoses, and they are associated with prolonged duration of immunosuppression.
Original language | English (US) |
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Pages (from-to) | 78-86 |
Number of pages | 9 |
Journal | Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology |
Volume | 13 |
Issue number | 1 |
DOIs | |
State | Published - 1996 |
Externally published | Yes |
Keywords
- AIDS
- Hemophilia
- Non-Hodgkin's lymphoma
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Virology