Alcohol-Associated Liver Disease Outcomes: Critical Mechanisms of Liver Injury Progression

Natalia A. Osna, Irina Tikhanovich, Martí Ortega-Ribera, Sebastian Mueller, Chaowen Zheng, Johannes Mueller, Siyuan Li, Sadatsugu Sakane, Raquel Carvalho Gontijo Weber, Hyun Young Kim, Wonseok Lee, Souradipta Ganguly, Yusuke Kimura, Xiao Liu, Debanjan Dhar, Karin Diggle, David A. Brenner, Tatiana Kisseleva, Neha Attal, Iain H. McKillopShilpa Chokshi, Ram Mahato, Karuna Rasineni, Gyongyi Szabo, Kusum K. Kharbanda

Research output: Contribution to journalReview articlepeer-review

Abstract

Alcohol-associated liver disease (ALD) is a substantial cause of morbidity and mortality worldwide and represents a spectrum of liver injury beginning with hepatic steatosis (fatty liver) progressing to inflammation and culminating in cirrhosis. Multiple factors contribute to ALD progression and disease severity. Here, we overview several crucial mechanisms related to ALD end-stage outcome development, such as epigenetic changes, cell death, hemolysis, hepatic stellate cells activation, and hepatic fatty acid binding protein 4. Additionally, in this review, we also present two clinically relevant models using human precision-cut liver slices and hepatic organoids to examine ALD pathogenesis and progression.

Original languageEnglish (US)
Article number404
JournalBiomolecules
Volume14
Issue number4
DOIs
StatePublished - Apr 2024

Keywords

  • MetAld
  • alcohol-associated liver disease
  • cell death
  • epigenetics
  • fatty acid binding protein 4
  • fibrosis
  • hemolysis
  • hepatic stellate cells
  • hepatocellular carcinoma
  • models

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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