Alcohol: basic and translational research; 15th annual Charles Lieber &1st Samuel French satellite symposium

Manuela G. Neuman, Helmut K. Seitz, Pamela L. Tuma, Natalia A. Osna, Carol A. Casey, Kusum K. Kharbanda, Lawrence B. Cohen, Steve D.H. Malnick, Raghabendra Adhikari, Ramyajit Mitra, Raghubendra Singh Dagur, Murali Ganesan, Chava Srinivas, Arumugam Madan Kumar, Moses New-Aaron, Larisa Poluektova, Paul G. Thomes, Karuna Rasineni, Mihai Opris, Rolf Teschke

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

The present review is based on the research presented at the symposium dedicated to the legacy of the two scientists that made important discoveries in the field of alcohol-induced liver damage: Professors C.S. Lieber and S.W. French. The invited speakers described pharmacological, toxicological and patho-physiological effects of alcohol misuse. Moreover, genetic biomarkers determining adverse drug reactions due to interactions between therapeutics used for chronic or infectious diseases and alcohol exposure were discussed. The researchers presented their work in areas of alcohol-induced impairment in lipid protein trafficking and endocytosis, as well as the role of lipids in the development of fatty liver. The researchers showed that alcohol leads to covalent modifications that promote hepatic dysfunction and injury. We concluded that using new advanced techniques and research ideas leads to important discoveries in science.

Original languageEnglish (US)
Article number104750
JournalExperimental and Molecular Pathology
Volume126
DOIs
StatePublished - Jun 2022

Keywords

  • Acetylation
  • Alcoholic liver disease
  • Human immunodeficiency virus
  • Hyaline Bodies, Lipid and protein traffic
  • Inflammation
  • Nonalcoholic liver disease
  • Nutrition
  • Tissue culture

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Clinical Biochemistry

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