TY - JOUR
T1 - Alcohol Consumption, Serum Gamma-Glutamyltransferase, and Helicobacter Pylori Infection in a Population-Based Study Among 9733 Older Adults
AU - Gao, Lei
AU - Weck, Melanie N.
AU - Stegmaier, Christa
AU - Rothenbacher, Dietrich
AU - Brenner, Hermann
N1 - Funding Information:
This study was supported by the Baden-Wuerttemberg State Ministry of Science, Research and Arts. The work of Lei Gao was supported by a scholarship from the German Academic Exchange Service (DAAD).
PY - 2010/2
Y1 - 2010/2
N2 - Purpose: Moderate alcohol consumption has been suggested to facilitate the elimination of Helicobacter pylori infection as the result of its antibacterial effect. We aimed to assess the associations of current and lifetime alcohol consumption as well as serum gamma-glutamyltransferase (GGT), an established biomarker of alcohol consumption, with H. pylori infection in a large population-based study. Methods: In the baseline examination of the ESTHER study, serological measurements of antibodies against H. pylori and GGT measurements were taken in 9733 subjects ages 50 to 74 years. Information on lifestyle factors and medical history were obtained by self-administered standardized questionnaire. Results: A significant inverse association, in dose-response manner, was observed between both current and lifetime alcohol consumption and H. pylori seropositivity. The estimates based on lifetime consumption were more pronounced than the results for current consumption, and such inverse associations were found both for men and women. Stronger relations were observed for those who only drank wine or mixed drinkers compare with those who only drank beer. Furthermore, there was a significant inverse dose-response relationship between serum GGT levels and H. pylori seropositivity, which was selectively observed among alcohol drinkers. Conclusions: In conclusion, our results support the hypothesis that moderate alcohol consumption may facilitate elimination of H. pylori.
AB - Purpose: Moderate alcohol consumption has been suggested to facilitate the elimination of Helicobacter pylori infection as the result of its antibacterial effect. We aimed to assess the associations of current and lifetime alcohol consumption as well as serum gamma-glutamyltransferase (GGT), an established biomarker of alcohol consumption, with H. pylori infection in a large population-based study. Methods: In the baseline examination of the ESTHER study, serological measurements of antibodies against H. pylori and GGT measurements were taken in 9733 subjects ages 50 to 74 years. Information on lifestyle factors and medical history were obtained by self-administered standardized questionnaire. Results: A significant inverse association, in dose-response manner, was observed between both current and lifetime alcohol consumption and H. pylori seropositivity. The estimates based on lifetime consumption were more pronounced than the results for current consumption, and such inverse associations were found both for men and women. Stronger relations were observed for those who only drank wine or mixed drinkers compare with those who only drank beer. Furthermore, there was a significant inverse dose-response relationship between serum GGT levels and H. pylori seropositivity, which was selectively observed among alcohol drinkers. Conclusions: In conclusion, our results support the hypothesis that moderate alcohol consumption may facilitate elimination of H. pylori.
KW - Alcohol Consumption
KW - Alcoholic Beverage
KW - Gamma-Glutamyltransferase
KW - Helicobacter pylori
KW - Population-Based
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U2 - 10.1016/j.annepidem.2009.11.009
DO - 10.1016/j.annepidem.2009.11.009
M3 - Article
C2 - 20123162
AN - SCOPUS:73249150360
SN - 1047-2797
VL - 20
SP - 122
EP - 128
JO - Annals of Epidemiology
JF - Annals of Epidemiology
IS - 2
ER -