@article{063dfad55e2c4234a0ebf409c595b0f6,
title = "Alcohol Use Disorder, But Not Cannabis Use Disorder, Symptomatology in Adolescents Is Associated With Reduced Differential Responsiveness to Reward Versus Punishment Feedback During Instrumental Learning",
abstract = "Background: The two most commonly used illegal substances by adolescents in the United States are alcohol and cannabis. Alcohol use disorder (AUD) and cannabis use disorder (CUD) have been associated with dysfunction in decision-making processes in adolescents. One potential mechanism for these impairments is thought to be related to abnormalities in reward and punishment processing. However, very little work has directly examined potential differential relationships between AUD and CUD symptom severity and neural dysfunction during decision making in adolescents. Methods: In the current study, 154 youths participated in a passive avoidance learning task during functional magnetic resonance imaging to investigate the relationship between relative severity of AUD/CUD and dysfunction in processing reward and punishment feedback. Results: Increasing Alcohol Use Disorder Identification Test scores were associated with reduced neural differentiation between reward and punishment feedback within regions of striatum, posterior cingulate cortex, and parietal cortex. However, increasing Cannabis Use Disorder Identification Test scores were not associated with any neural dysfunction during the passive avoidance task. Conclusions: These data expand on emerging literature that relative severity of AUD is associated with reduced responsivity to rewards in adolescents and that there are differential associations between AUD and CUD symptoms and neurocircuitry dysfunction in the developing adolescent brain.",
keywords = "Adolescent, Alcohol use disorder, Instrumental learning, Reward, Striatum, fMRI",
author = "Joseph Aloi and Blair, {Karina S.} and Crum, {Kathleen I.} and Johannah Bashford-Largo and Ru Zhang and Jennie Lukoff and Erin Carollo and White, {Stuart F.} and Soonjo Hwang and Filbey, {Francesca M.} and Matthew Dobbertin and Blair, {R. James R.}",
note = "Funding Information: This work was supported by Boys Town National Research Hospital. JA was supported by the American Academy of Child and Adolescent Psychiatry (AACAP) Jeanne Spurlock Medical Student Research Fellowship in Substance Abuse and Addiction and by a Program of Excellence Fellowship from the University of Nebraska Medical Center . RJRB This work was supported by National Institute of Mental Health (NIMH) Grant Nos. K22-MH109558 (to RJRB), R34-DA050286 (to RJRB), Grant No. K01-MH110643 (to SFW), and T32-MH018869 (to KIC); National Institute of General Medical Sciences Grant No. P20-GM109023 (to KSB); and National Institute on Drug Abuse Grant No. U54-DA016511 (to KIC). The funders had no role in study design, data collection, data analysis, decision to publish, or manuscript preparation. Funding Information: This work was supported by Boys Town National Research Hospital. JA was supported by the American Academy of Child and Adolescent Psychiatry (AACAP) Jeanne Spurlock Medical Student Research Fellowship in Substance Abuse and Addiction and by a Program of Excellence Fellowship from the University of Nebraska Medical Center. RJRB This work was supported by National Institute of Mental Health (NIMH) Grant Nos. K22-MH109558 (to RJRB), R34-DA050286 (to RJRB), Grant No. K01-MH110643 (to SFW), and T32-MH018869 (to KIC); National Institute of General Medical Sciences Grant No. P20-GM109023 (to KSB); and National Institute on Drug Abuse Grant No. U54-DA016511 (to KIC). The funders had no role in study design, data collection, data analysis, decision to publish, or manuscript preparation. We thank Ron Copsey, Kim VanHorn, Michael Wright, Mark Timm, and Rhonda Tuel for their contributions to data collection. We also thank all participants and their families for their participation. The authors report no biomedical financial interests or potential conflicts of interest.",
year = "2020",
month = jun,
doi = "10.1016/j.bpsc.2020.02.003",
language = "English (US)",
volume = "5",
pages = "610--618",
journal = "Biological Psychiatry: Cognitive Neuroscience and Neuroimaging",
issn = "2451-9022",
publisher = "Elsevier Inc.",
number = "6",
}