Alcoholic liver disease: Clinical and translational research

Manuela G. Neuman, Stephen Malnick, Yaakov Maor, Radu M. Nanau, Ehud Melzer, Peter Ferenci, Helmut K. Seitz, Sebastian Mueller, Haim Mell, Didier Samuel, Lawrence B. Cohen, Kusum K. Kharbanda, Natalia A. Osna, Murali Ganesan, Kyle J. Thompson, Iain H. McKillop, Abraham Bautista, Ramon Bataller, Samuel W. French

Research output: Contribution to journalReview article

21 Scopus citations

Abstract

The present review spans a broad spectrum of topics dealing with alcoholic liver disease (ALD), including clinical research, translational research, pathogenesis and therapies. A special accent is placed on alcohol misuse, as alcohol is a legally commercialized and taxable product. Drinking alcohol, particularly from a young age, is a major health problem. Alcoholism is known to contribute to morbidity and mortality. A systematic literature search was performed in order to obtain updated data (2008-2015). The review is focused on genetic polymorphisms of alcohol metabolizing enzymes and the role of cytochrome p450 2E1 and iron in ALD. Alcohol-mediated hepatocarcinogenesis is also discussed in the presence or absence of co-morbidities such as viral hepatitis C as well as therapeutic the role of innate immunity in ALD-HCV. Moreover, emphasis was placed on alcohol and drug interactions, as well as liver transplantation for end-stage ALD. Finally, the time came to eradicate alcohol-induced liver and intestinal damage by using betaine.

Original languageEnglish (US)
Pages (from-to)596-610
Number of pages15
JournalExperimental and Molecular Pathology
Volume99
Issue number3
DOIs
StatePublished - Dec 1 2015

Keywords

  • Alcohol dehydrogenase
  • Alcoholic liver disease
  • Betaine
  • CYP2E1
  • Hepatitis B and C viral infection
  • Hepatocarcinogenesis
  • Human immunodeficiency virus
  • Liver fibrosis
  • Liver transplant

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Clinical Biochemistry

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