Alcoholic liver disease: Quantitative image-guided P-31 MR spectroscopy

D. J. Meyerhoff, M. D. Boska, A. M. Thomas, M. W. Weiner

Research output: Contribution to journalArticle

80 Scopus citations

Abstract

Phosphorus-31 magnetic resonance (MR) spectroscopy was performed on the liver of patients with alcoholic hepatitis (n=10), alcoholic cirrhosis (n=9), and viral hepatitis B (n=3) and on healthy control subjects (n=21). A hydrogen-1 MR image-guided localization technique (ISIS) was used to acquire P-31 spectra selectively from a volume of interest within the liver. Spectra were analyzed to yield absolute molar concentrations of hepatic phosphomonoesters, phosphodiesters, inorganic phosphate, and adenosine triphosphate. It was found that (a) hepatic metabolite ratios in alcoholic liver disease were not significantly different from those in healthy subjects, (b) absolute hepatic metabolite concentrations were decreased by 25%-46% in alcoholic hepatitis and 13%-50% in alcoholic cirrhosis compared with those in healthy subjects, and (c) hepatic intracellular pH was 7.4 in healthy subjects, more acidic in alcoholic cirrhosis, and more alkaline in alcoholic hepatitis. The findings indicate that hepatic metabolite ratios are not a sensitive measure of alcoholic liver disease, that quantitative P-31 MR spectroscopy is able to noninvasively show metabolic changes associated with alcoholic liver disease, and that alcoholic hepatitis and cirrhosis may be distinguished by means of hepatic intracellular pH measured with MR spectroscopy.

Original languageEnglish (US)
Pages (from-to)393-400
Number of pages8
JournalRadiology
Volume173
Issue number2
DOIs
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Alcoholic liver disease: Quantitative image-guided P-31 MR spectroscopy'. Together they form a unique fingerprint.

  • Cite this

    Meyerhoff, D. J., Boska, M. D., Thomas, A. M., & Weiner, M. W. (1989). Alcoholic liver disease: Quantitative image-guided P-31 MR spectroscopy. Radiology, 173(2), 393-400. https://doi.org/10.1148/radiology.173.2.2798871