Abstract
Aldose reductase (EC 1.1.1.21) has been implicated in a variety of diabetic complications. Here we present the first primary sequence data for the rat lens enzyme, obtained by amino acid and cDNA analysis. We have found structural similarities with another NADPH-dependent oxidoreductase: human liver aldehyde reductase (EC 1.1.1.2). The identity between these two enzymes is 50%. Both enzymes share approx. 40-50% homology with ρ{variant}-crystallin, a major lens protein present only in the frog, Rana pipiens. We propose that aldose reductase, aldehyde reductase and ρ{variant}-crystallin are members of a superfamily of related proteins.
Original language | English (US) |
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Pages (from-to) | 209-213 |
Number of pages | 5 |
Journal | FEBS Letters |
Volume | 220 |
Issue number | 1 |
DOIs | |
State | Published - Aug 10 1987 |
Externally published | Yes |
Keywords
- Aldehyde reductase
- Aldose reductase
- Structural homology
- cDNA sequence
- ρ{variant}-Crystallin
ASJC Scopus subject areas
- Biophysics
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology