Aldose reductase localization in dog retinal mural cells

Yoshio Akagi, Hirofumi Terubayashi, Jane Millen, Peter F. Kador, Jin H. Kinoshita

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


The selective degeneration of retinal mural cells, a hallmark of early human diabetic retinopathy, has also been reported to occur in both diabetic and galactose-fed dogs. By employing antibodies raised against purified dog lens aldose reductase the presence of aldose reductase can be immunohisto-chemically demonstrated in the cytoplasm of mural cells but not endothelial cells of dog retinal vessels isolated by trypsin digestion. This immunohisto-chemical staining is similar to that observed with isolated human retinal vessels.

Original languageEnglish (US)
Pages (from-to)883-886
Number of pages4
JournalCurrent Eye Research
Issue number11
StatePublished - 1986

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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