TY - JOUR
T1 - Aldose reductase localization in dog retinal mural cells
AU - Akagi, Yoshio
AU - Terubayashi, Hirofumi
AU - Millen, Jane
AU - Kador, Peter F.
AU - Kinoshita, Jin H.
PY - 1986
Y1 - 1986
N2 - The selective degeneration of retinal mural cells, a hallmark of early human diabetic retinopathy, has also been reported to occur in both diabetic and galactose-fed dogs. By employing antibodies raised against purified dog lens aldose reductase the presence of aldose reductase can be immunohisto-chemically demonstrated in the cytoplasm of mural cells but not endothelial cells of dog retinal vessels isolated by trypsin digestion. This immunohisto-chemical staining is similar to that observed with isolated human retinal vessels.
AB - The selective degeneration of retinal mural cells, a hallmark of early human diabetic retinopathy, has also been reported to occur in both diabetic and galactose-fed dogs. By employing antibodies raised against purified dog lens aldose reductase the presence of aldose reductase can be immunohisto-chemically demonstrated in the cytoplasm of mural cells but not endothelial cells of dog retinal vessels isolated by trypsin digestion. This immunohisto-chemical staining is similar to that observed with isolated human retinal vessels.
UR - http://www.scopus.com/inward/record.url?scp=0022980775&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022980775&partnerID=8YFLogxK
U2 - 10.3109/02713688609029241
DO - 10.3109/02713688609029241
M3 - Article
C2 - 3096638
AN - SCOPUS:0022980775
SN - 0271-3683
VL - 5
SP - 883
EP - 886
JO - Current Eye Research
JF - Current Eye Research
IS - 11
ER -