Aldose reductase localization in human retinal mural cells

Y. Akagi, P. F. Kador, T. Kuwabara, J. H. Kinoshita

Research output: Contribution to journalArticlepeer-review

123 Scopus citations


A hallmark of early diabetic retinopathy is the selective loss of the retinal mural cells (pericytes) from vessels. Using antibodies prepared against purified human placental aldose reductase, the presence of the enzyme aldose reductase can be demonstrated immunohistochemically in the cytoplasm of retinal mural cells of trypsin-digested human retinal vessels. This enzyme, which reduces various hexose sugars to their sugar alcohols, has been implicated in the pathogenesis of several diabetic complications.

Original languageEnglish (US)
Pages (from-to)1516-1519
Number of pages4
JournalInvestigative Ophthalmology and Visual Science
Issue number11
StatePublished - 1983

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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