"Aligned-to-random" nanofiber scaffolds for mimicking the structure of the tendon-to-bone insertion site

Jingwei Xie, Xiaoran Li, Justin Lipner, Cionne N. Manning, Annie G. Schwartz, Stavros Thomopoulos, Younan Xia

Research output: Contribution to journalArticle

141 Scopus citations

Abstract

We have demonstrated the fabrication of "aligned-to-random" electrospun nanofiber scaffolds that mimic the structural organization of collagen fibers at the tendon-to-bone insertion site. Tendon fibroblasts cultured on such a scaffold exhibited highly organized and haphazardly oriented morphologies, respectively, on the aligned and random portions.

Original languageEnglish (US)
Pages (from-to)923-926
Number of pages4
JournalNanoscale
Volume2
Issue number6
DOIs
StatePublished - Jun 14 2010

ASJC Scopus subject areas

  • Materials Science(all)

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    Xie, J., Li, X., Lipner, J., Manning, C. N., Schwartz, A. G., Thomopoulos, S., & Xia, Y. (2010). "Aligned-to-random" nanofiber scaffolds for mimicking the structure of the tendon-to-bone insertion site. Nanoscale, 2(6), 923-926. https://doi.org/10.1039/c0nr00192a