"Aligned-to-random" nanofiber scaffolds for mimicking the structure of the tendon-to-bone insertion site

Jingwei Xie; Xiaoran Li; Justin Lipner; Cionne N. Manning; Annie G. Schwartz; Stavros Thomopoulos; Younan Xia

doi:10.1039/c0nr00192a

"Aligned-to-random" nanofiber scaffolds for mimicking the structure of the tendon-to-bone insertion site

Jingwei Xie, Xiaoran Li, Justin Lipner, Cionne N. Manning, Annie G. Schwartz, Stavros Thomopoulos, Younan Xia

Research output: Contribution to journal › Article › peer-review

145 Scopus citations

Abstract

We have demonstrated the fabrication of "aligned-to-random" electrospun nanofiber scaffolds that mimic the structural organization of collagen fibers at the tendon-to-bone insertion site. Tendon fibroblasts cultured on such a scaffold exhibited highly organized and haphazardly oriented morphologies, respectively, on the aligned and random portions.

Original language	English (US)
Pages (from-to)	923-926
Number of pages	4
Journal	Nanoscale
Volume	2
Issue number	6
DOIs	https://doi.org/10.1039/c0nr00192a
State	Published - 2010
Externally published	Yes

ASJC Scopus subject areas

Materials Science(all)

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10.1039/c0nr00192a

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abstract = "We have demonstrated the fabrication of {"}aligned-to-random{"} electrospun nanofiber scaffolds that mimic the structural organization of collagen fibers at the tendon-to-bone insertion site. Tendon fibroblasts cultured on such a scaffold exhibited highly organized and haphazardly oriented morphologies, respectively, on the aligned and random portions.",

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AU - Schwartz, Annie G.

AU - Thomopoulos, Stavros

AU - Xia, Younan

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