"Aligned-to-random" nanofiber scaffolds for mimicking the structure of the tendon-to-bone insertion site

Jingwei Xie, Xiaoran Li, Justin Lipner, Cionne N. Manning, Annie G. Schwartz, Stavros Thomopoulos, Younan Xia

Research output: Contribution to journalArticlepeer-review

145 Scopus citations

Abstract

We have demonstrated the fabrication of "aligned-to-random" electrospun nanofiber scaffolds that mimic the structural organization of collagen fibers at the tendon-to-bone insertion site. Tendon fibroblasts cultured on such a scaffold exhibited highly organized and haphazardly oriented morphologies, respectively, on the aligned and random portions.

Original languageEnglish (US)
Pages (from-to)923-926
Number of pages4
JournalNanoscale
Volume2
Issue number6
DOIs
StatePublished - 2010
Externally publishedYes

ASJC Scopus subject areas

  • Materials Science(all)

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