TY - GEN
T1 - Alteration of Notch signaling in skeletal development and disease
AU - Tao, Jianning
AU - Chen, Shan
AU - Lee, Brendan
PY - 2010/3
Y1 - 2010/3
N2 - Notch signaling is an evolutionarily conserved mechanism for specifying and regulating organogenesis and tissue renewal. Human and mouse genetic studies have demonstrated mutations in many components of the Notch signaling pathway that cause skeletal patterning defects. More recently, the in vivo effects of Notch signaling on osteoblast specification, proliferation, and differentiation have been demonstrated in addition to its regulation of osteoclast activity. However, while our understanding of canonical Notch signaling in skeletal biology is rapidly evolving, the role of noncanonical Notch signaling is still poorly understood. In a pathologic context, aberration of Notch signaling is also associated with osteosarcoma. These studies raise the question of how Notch may interact with other signaling pathways, such as Wnt. Finally, manipulation of Notch signaling for bone-related diseases remains complex because of the temporal and context-dependent nature of Notch signaling during mesenchymal stem cell and osteoblast differentiation.
AB - Notch signaling is an evolutionarily conserved mechanism for specifying and regulating organogenesis and tissue renewal. Human and mouse genetic studies have demonstrated mutations in many components of the Notch signaling pathway that cause skeletal patterning defects. More recently, the in vivo effects of Notch signaling on osteoblast specification, proliferation, and differentiation have been demonstrated in addition to its regulation of osteoclast activity. However, while our understanding of canonical Notch signaling in skeletal biology is rapidly evolving, the role of noncanonical Notch signaling is still poorly understood. In a pathologic context, aberration of Notch signaling is also associated with osteosarcoma. These studies raise the question of how Notch may interact with other signaling pathways, such as Wnt. Finally, manipulation of Notch signaling for bone-related diseases remains complex because of the temporal and context-dependent nature of Notch signaling during mesenchymal stem cell and osteoblast differentiation.
KW - Chondrocytes
KW - Noncanonical signaling
KW - Notch signaling
KW - Osteoblast differentiation
KW - Osteoclasts
KW - Osteosarcoma
KW - Skeletal defects
UR - http://www.scopus.com/inward/record.url?scp=77950679225&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77950679225&partnerID=8YFLogxK
U2 - 10.1111/j.1749-6632.2009.05307.x
DO - 10.1111/j.1749-6632.2009.05307.x
M3 - Conference contribution
C2 - 20392245
AN - SCOPUS:77950679225
SN - 9781573317856
T3 - Annals of the New York Academy of Sciences
SP - 257
EP - 268
BT - Skeletal Biology and Medicine
PB - Blackwell Publishing Inc.
ER -