Alterations in the rat kidney associated with sodium saccharin feeding: A scanning electron microscopic study

Theodore D. Miller; Samuel M. Cohen

doi:10.1016/0378-4274(84)90144-9

Alterations in the rat kidney associated with sodium saccharin feeding: A scanning electron microscopic study

Theodore D. Miller, Samuel M. Cohen

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6 Scopus citations

Abstract

Sodium saccharin has previously been demonstrated to induce hyperplasia of the urothelium of the rat kidney pelvis. It was fed as 5% of the diet to male F344 rats for 18 weeks. In the present experiment, scanning electron microscopy (SEM) was utilized to detect early morphologic changes. Pleomorphic microvilli (PMV) were observed in all four sodium saccharin-fed rats, located on cells at the junction of the papilla and pelvis. PMV also occurred at the papilla-pelvic junction in three of the ten control rats, but the affected area was smaller and the PMV exhibited less severe atypia.

Original language	English (US)
Pages (from-to)	177-181
Number of pages	5
Journal	Toxicology Letters
Volume	20
Issue number	2
DOIs	https://doi.org/10.1016/0378-4274(84)90144-9
State	Published - Feb 1984

Keywords

Pelvis
hyperplasia
microvilli
saccharin
scanning electron microscopy

ASJC Scopus subject areas

Toxicology

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10.1016/0378-4274(84)90144-9

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@article{f251e3a727d648e6b4b491f9f10d2463,

title = "Alterations in the rat kidney associated with sodium saccharin feeding: A scanning electron microscopic study",

abstract = "Sodium saccharin has previously been demonstrated to induce hyperplasia of the urothelium of the rat kidney pelvis. It was fed as 5% of the diet to male F344 rats for 18 weeks. In the present experiment, scanning electron microscopy (SEM) was utilized to detect early morphologic changes. Pleomorphic microvilli (PMV) were observed in all four sodium saccharin-fed rats, located on cells at the junction of the papilla and pelvis. PMV also occurred at the papilla-pelvic junction in three of the ten control rats, but the affected area was smaller and the PMV exhibited less severe atypia.",

keywords = "Pelvis, hyperplasia, microvilli, saccharin, scanning electron microscopy",

author = "Miller, {Theodore D.} and Cohen, {Samuel M.}",

note = "Funding Information: This investigation was supported in part by USPHS Grant CA325 13 from the National Cancer Institute through the National Bladder Cancer Project. We thank Drs. Richard B. Wilson, Toru Suzuki, Gen{\textquoteright}i Murasaki, and Ryohei Hasegawa for their advice and comments, Margaret St. John and Martin Cano for technical assistance, and Jan Leemkuil for assistance in the preparation of this manuscript.",

year = "1984",

month = feb,

doi = "10.1016/0378-4274(84)90144-9",

language = "English (US)",

volume = "20",

pages = "177--181",

journal = "Toxicology Letters",

issn = "0378-4274",

publisher = "Elsevier Ireland Ltd",

number = "2",

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TY - JOUR

T1 - Alterations in the rat kidney associated with sodium saccharin feeding

T2 - A scanning electron microscopic study

AU - Miller, Theodore D.

AU - Cohen, Samuel M.

N1 - Funding Information: This investigation was supported in part by USPHS Grant CA325 13 from the National Cancer Institute through the National Bladder Cancer Project. We thank Drs. Richard B. Wilson, Toru Suzuki, Gen’i Murasaki, and Ryohei Hasegawa for their advice and comments, Margaret St. John and Martin Cano for technical assistance, and Jan Leemkuil for assistance in the preparation of this manuscript.

PY - 1984/2

Y1 - 1984/2

N2 - Sodium saccharin has previously been demonstrated to induce hyperplasia of the urothelium of the rat kidney pelvis. It was fed as 5% of the diet to male F344 rats for 18 weeks. In the present experiment, scanning electron microscopy (SEM) was utilized to detect early morphologic changes. Pleomorphic microvilli (PMV) were observed in all four sodium saccharin-fed rats, located on cells at the junction of the papilla and pelvis. PMV also occurred at the papilla-pelvic junction in three of the ten control rats, but the affected area was smaller and the PMV exhibited less severe atypia.

AB - Sodium saccharin has previously been demonstrated to induce hyperplasia of the urothelium of the rat kidney pelvis. It was fed as 5% of the diet to male F344 rats for 18 weeks. In the present experiment, scanning electron microscopy (SEM) was utilized to detect early morphologic changes. Pleomorphic microvilli (PMV) were observed in all four sodium saccharin-fed rats, located on cells at the junction of the papilla and pelvis. PMV also occurred at the papilla-pelvic junction in three of the ten control rats, but the affected area was smaller and the PMV exhibited less severe atypia.

KW - Pelvis

KW - hyperplasia

KW - microvilli

KW - saccharin

KW - scanning electron microscopy

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DO - 10.1016/0378-4274(84)90144-9

M3 - Article

C2 - 6695409

AN - SCOPUS:0021368389

SN - 0378-4274

VL - 20

SP - 177

EP - 181

JO - Toxicology Letters

JF - Toxicology Letters

IS - 2

ER -

Alterations in the rat kidney associated with sodium saccharin feeding: A scanning electron microscopic study

Abstract

Keywords

ASJC Scopus subject areas

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