Altered Biatrial Phasic Function after Heart Transplantation in Children

Anitha Parthiban, Vivek Jani, Jin Zhang, Ling Li, Mary Craft, Aleissa Barnes, Jean A. Ballweg, Andreas Schuster, David A. Danford, Shelby Kutty

Research output: Contribution to journalArticle

Abstract

Purpose: We used two-dimensional echocardiographic speckle-tracking to investigate whether left and right atrial (LA and RA) phasic function in pediatric heart transplantation (HT) patients is altered and explored the relationship to HT-related clinical variables. Methods: Eighty-six subjects (36 HT and 50 normal children) were prospectively enrolled in two centers. Clinical data included age at HT, bypass time, ischemia time, donor age, and incidence of rejection. Atrial deformation indices including strain and strain rates (SRs) were measured using two-dimensional echocardiographic speckle-tracking. Components of phasic atrial function—reservoir (εr, SRr), conduit (εcd, SRcd), and booster (εct, SRct) were calculated. Comparisons with controls were made using t test or Kruskal-Wallis test, and correlations to clinical variables were explored. Results: The mean age and body surface area of HT subjects were 10.2 ± 6.2 years and 1.2 ± 0.6 m2, respectively. The mean heart rates were higher in HT (96 ± 18 vs 88 ± 21 in controls). There were reductions in RA and LA reservoir (εr, SRr), conduit (εcd, SRcd), and booster (εct, SRct) function in HT compared with controls. There was no relationship of LA and RA deformation indices with mean age at HT, bypass time, or ischemia time. The LA εcd correlated weakly with donor age (r = –0.49, P =.04) and RA SRr, and SRcd showed association with duration of HT (P <.05). Nineteen HT recipients had follow-up studies 0.24 ± 0.18 years after the first examination, and deformational indices were not significantly changed. Conclusions: Atrial strain determination is feasible in pediatric HT recipients and demonstrates disruption of reservoir, conduit, and booster function of both atria in this population; we speculate this may be a consequence of ventricular diastolic dysfunction.

Original languageEnglish (US)
Pages (from-to)1132-1140.e2
JournalJournal of the American Society of Echocardiography
Volume33
Issue number9
DOIs
StatePublished - Sep 2020

Keywords

  • Atrial strain
  • Atrial strain rate
  • Heart transplantation
  • Pediatric cardiology
  • Two-dimensional speckle-tracking

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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    Parthiban, A., Jani, V., Zhang, J., Li, L., Craft, M., Barnes, A., Ballweg, J. A., Schuster, A., Danford, D. A., & Kutty, S. (2020). Altered Biatrial Phasic Function after Heart Transplantation in Children. Journal of the American Society of Echocardiography, 33(9), 1132-1140.e2. https://doi.org/10.1016/j.echo.2020.04.029