Altered expression of MUC2 and MUC5AC in response to Shigella infection, an in vivo study

Prakash Radhakrishnan, Devaraj Halagowder, S. Niranjali Devaraj

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Infection of mucosal epithelial cells by Shigella species leads to an intense and acute inflammatory bowel disease that is characterized by watery diarrhea and purulent discharge. Mucin production is a common defense mechanism to protect the underlying mucosa against pathogens. The molecular mechanism(s) underlying mucin induction is unknown in Shigellosis. In this study, we have evaluated the relationship between Shigella infection, the expression of MUC2 and MUC5AC and the participation of signaling molecules TNF-α, PKC and ERK1/2. Shigella infection up-regulated MUC2 and MUC5AC expression in 6-8 h, through activation of TNF-α, PKC and ERK1/2. These results confirm that, in response to Shigella infection, the normal expression pattern of MUC-2 and MUC-5AC is altered. This in vivo study brings new insights into the molecular pathogenesis of Shigellosis and new potential therapeutic targets for Shigellosis.

Original languageEnglish (US)
Pages (from-to)884-889
Number of pages6
JournalBiochimica et Biophysica Acta - General Subjects
Volume1770
Issue number6
DOIs
StatePublished - Jun 1 2007

Keywords

  • Ileal loop ligation assay
  • MUC2
  • MUC5AC
  • Shigella species
  • Shigellosis

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology

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