Altered metabolomic profile in patients with peripheral artery disease

Ahmed Ismaeel, Marco E. Franco, Ramon Lavado, Evlampia Papoutsi, George P. Casale, Matthew Fuglestad, Constance J. Mietus, Gleb R. Haynatzki, Robert S. Smith, William T. Bohannon, Ian Sawicki, Iraklis I. Pipinos, Panagiotis Koutakis

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Peripheral artery disease (PAD) is a common atherosclerotic disease characterized by narrowed or blocked arteries in the lower extremities. Circulating serum biomarkers can provide significant insight regarding the disease progression. Here, we explore the metabolomics signatures associated with different stages of PAD and investigate potential mechanisms of the disease. We compared the serum metabolites of a cohort of 26 PAD patients presenting with claudication and 26 PAD patients presenting with critical limb ischemia (CLI) to those of 26 non-PAD controls. A difference between the metabolite profiles of PAD patients from non-PAD controls was observed for several amino acids, acylcarnitines, ceramides, and cholesteryl esters. Furthermore, our data demonstrate that patients with CLI possess an altered metabolomic signature different from that of both claudicants and non-PAD controls. These findings provide new insight into the pathophysiology of PAD and may help develop future diagnostic procedures and therapies for PAD patients.

Original languageEnglish (US)
Article number1463
JournalJournal of Clinical Medicine
Issue number9
StatePublished - Sep 2019


  • Claudication
  • Critical limb ischemia (CLI)
  • Metabolomics
  • Peripheral artery disease (PAD)

ASJC Scopus subject areas

  • Medicine(all)


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