Altered multiaxial mechanical properties of the porcine anterior lens capsule cultured in high glucose

R. M. Pedrigi, E. Staff, G. David, S. Glenn, J. D. Humphrey

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Hyperglycemia can alter the mechanical properties of tissues through the formation of advanced glycation endproducts in matrix proteins that have long half-lives. We used a custom experimental system and subdomain finite element method to quantify alterations in the regional multiaxial mechanical properties of porcine lens capsules that were cultured for 8 or 14 weeks in high glucose versus control media. Findings revealed that high glucose significantly stiffened the capsules in both the circumferential and the meridional directions, but it did not affect the known regional variations in anisotropy. Such information could be important in the design of both improved clinical procedures and intraocular implants for diabetic patients.

Original languageEnglish (US)
Pages (from-to)121-125
Number of pages5
JournalJournal of Biomechanical Engineering
Volume129
Issue number1
DOIs
StatePublished - Feb 2007
Externally publishedYes

Keywords

  • Biomechanics
  • Cataracts
  • Diabetes
  • Hyperglycemia
  • Type IV collagen

ASJC Scopus subject areas

  • Biomedical Engineering
  • Physiology (medical)

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