Amarogentin, a naturally occurring secoiridoid glycoside and a newly recognized inhibitor of topoisomerase I from Leishmania donovani

Sutapa Ray; Hemanta K. Majumder; Ajit K. Chakravarty; Sibabrata Mukhopadhyay; Roberto R. Gil; Geoffrey A. Cordell

doi:10.1021/np960018g

Amarogentin, a naturally occurring secoiridoid glycoside and a newly recognized inhibitor of topoisomerase I from Leishmania donovani

Sutapa Ray, Hemanta K. Majumder, Ajit K. Chakravarty, Sibabrata Mukhopadhyay, Roberto R. Gil, Geoffrey A. Cordell

Research output: Contribution to journal › Article › peer-review

104 Scopus citations

Abstract

A MeOH extract of Swertia chirata found to inhibit the catalytic activity of topoisomerase I of Leishmania donovani was subjected to fractionation to yield three secoiridoid glycosides: amarogentin (1), amaroswerin (2), and sweroside (3). Amarogentin is a potent inhibitor of type I DNA topoisomerase from Leishmania and exerts its effect by interaction with the enzyme, preventing binary complex formation.

Original language	English (US)
Pages (from-to)	27-29
Number of pages	3
Journal	Journal of Natural Products
Volume	59
Issue number	1
DOIs	https://doi.org/10.1021/np960018g
State	Published - Jan 1996
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

Access to Document

10.1021/np960018g

Cite this

@article{3426043a50ef4cd2ab731bee3b587d01,

title = "Amarogentin, a naturally occurring secoiridoid glycoside and a newly recognized inhibitor of topoisomerase I from Leishmania donovani",

abstract = "A MeOH extract of Swertia chirata found to inhibit the catalytic activity of topoisomerase I of Leishmania donovani was subjected to fractionation to yield three secoiridoid glycosides: amarogentin (1), amaroswerin (2), and sweroside (3). Amarogentin is a potent inhibitor of type I DNA topoisomerase from Leishmania and exerts its effect by interaction with the enzyme, preventing binary complex formation.",

author = "Sutapa Ray and Majumder, {Hemanta K.} and Chakravarty, {Ajit K.} and Sibabrata Mukhopadhyay and Gil, {Roberto R.} and Cordell, {Geoffrey A.}",

year = "1996",

month = jan,

doi = "10.1021/np960018g",

language = "English (US)",

volume = "59",

pages = "27--29",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "1",

}

TY - JOUR

T1 - Amarogentin, a naturally occurring secoiridoid glycoside and a newly recognized inhibitor of topoisomerase I from Leishmania donovani

AU - Ray, Sutapa

AU - Majumder, Hemanta K.

AU - Chakravarty, Ajit K.

AU - Mukhopadhyay, Sibabrata

AU - Gil, Roberto R.

AU - Cordell, Geoffrey A.

PY - 1996/1

Y1 - 1996/1

N2 - A MeOH extract of Swertia chirata found to inhibit the catalytic activity of topoisomerase I of Leishmania donovani was subjected to fractionation to yield three secoiridoid glycosides: amarogentin (1), amaroswerin (2), and sweroside (3). Amarogentin is a potent inhibitor of type I DNA topoisomerase from Leishmania and exerts its effect by interaction with the enzyme, preventing binary complex formation.

AB - A MeOH extract of Swertia chirata found to inhibit the catalytic activity of topoisomerase I of Leishmania donovani was subjected to fractionation to yield three secoiridoid glycosides: amarogentin (1), amaroswerin (2), and sweroside (3). Amarogentin is a potent inhibitor of type I DNA topoisomerase from Leishmania and exerts its effect by interaction with the enzyme, preventing binary complex formation.

UR - http://www.scopus.com/inward/record.url?scp=0030465293&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030465293&partnerID=8YFLogxK

U2 - 10.1021/np960018g

DO - 10.1021/np960018g

M3 - Article

C2 - 8984149

AN - SCOPUS:0030465293

SN - 0163-3864

VL - 59

SP - 27

EP - 29

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 1

ER -

Amarogentin, a naturally occurring secoiridoid glycoside and a newly recognized inhibitor of topoisomerase I from Leishmania donovani

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this