Amine Peroxides as Potential Antimalarials

Jonathan L. Vennerstrom

doi:10.1021/jm00121a013

Amine Peroxides as Potential Antimalarials

Jonathan L. Vennerstrom

Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Six model amine peroxides (4–9) were synthesized as targeted antimalarial oxidants. They were approximately 1 order of magnitude more potent than tert-butyl hydroperoxide (3) in vitro against Plasmodium falciparum, but like 3, they were inactive in vivo against Plasmodium berghei.

Original language	English (US)
Pages (from-to)	64-67
Number of pages	4
Journal	Journal of Medicinal Chemistry
Volume	32
Issue number	1
DOIs	https://doi.org/10.1021/jm00121a013
State	Published - Jan 1 1989

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

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10.1021/jm00121a013

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title = "Amine Peroxides as Potential Antimalarials",

abstract = "Six model amine peroxides (4–9) were synthesized as targeted antimalarial oxidants. They were approximately 1 order of magnitude more potent than tert-butyl hydroperoxide (3) in vitro against Plasmodium falciparum, but like 3, they were inactive in vivo against Plasmodium berghei.",

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AB - Six model amine peroxides (4–9) were synthesized as targeted antimalarial oxidants. They were approximately 1 order of magnitude more potent than tert-butyl hydroperoxide (3) in vitro against Plasmodium falciparum, but like 3, they were inactive in vivo against Plasmodium berghei.

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Amine Peroxides as Potential Antimalarials

Abstract

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