Amine Peroxides as Potential Antimalarials

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Six model amine peroxides (4–9) were synthesized as targeted antimalarial oxidants. They were approximately 1 order of magnitude more potent than tert-butyl hydroperoxide (3) in vitro against Plasmodium falciparum, but like 3, they were inactive in vivo against Plasmodium berghei.

Original languageEnglish (US)
Pages (from-to)64-67
Number of pages4
JournalJournal of Medicinal Chemistry
Volume32
Issue number1
DOIs
StatePublished - Jan 1 1989

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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