Amino functionalized novel cholic acid derivatives induce HIV-1 replication and syncytia formation in T cells

Deepak B. Salunke; Dyavar S. Ravi; Vandana S. Pore; Debashis Mitra; Braja G. Hazra

doi:10.1021/jm051114u

Amino functionalized novel cholic acid derivatives induce HIV-1 replication and syncytia formation in T cells

Deepak B. Salunke, Dyavar S. Ravi, Vandana S. Pore, Debashis Mitra, Braja G. Hazra

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Synthesis of C-11 azido/amino functionalized cholic acid derivatives has been achieved in excellent yields. Contrary to the previous prediction of analogous compounds to be HIV-1 protease inhibitors, in the present study these novel cholic acid derivatives induced host cell fusion during the progress of HIV-1 infection and produced multinucleated giant cells. This is the first report of syncytia induction and enhancement of viral replication in HIV-1 infected T cells by cholic acid derivatives.

Original language	English (US)
Pages (from-to)	2652-2655
Number of pages	4
Journal	Journal of Medicinal Chemistry
Volume	49
Issue number	8
DOIs	https://doi.org/10.1021/jm051114u
State	Published - Apr 20 2006
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

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10.1021/jm051114u

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abstract = "Synthesis of C-11 azido/amino functionalized cholic acid derivatives has been achieved in excellent yields. Contrary to the previous prediction of analogous compounds to be HIV-1 protease inhibitors, in the present study these novel cholic acid derivatives induced host cell fusion during the progress of HIV-1 infection and produced multinucleated giant cells. This is the first report of syncytia induction and enhancement of viral replication in HIV-1 infected T cells by cholic acid derivatives.",

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AU - Salunke, Deepak B.

AU - Ravi, Dyavar S.

AU - Pore, Vandana S.

AU - Mitra, Debashis

AU - Hazra, Braja G.

PY - 2006/4/20

Y1 - 2006/4/20

N2 - Synthesis of C-11 azido/amino functionalized cholic acid derivatives has been achieved in excellent yields. Contrary to the previous prediction of analogous compounds to be HIV-1 protease inhibitors, in the present study these novel cholic acid derivatives induced host cell fusion during the progress of HIV-1 infection and produced multinucleated giant cells. This is the first report of syncytia induction and enhancement of viral replication in HIV-1 infected T cells by cholic acid derivatives.

AB - Synthesis of C-11 azido/amino functionalized cholic acid derivatives has been achieved in excellent yields. Contrary to the previous prediction of analogous compounds to be HIV-1 protease inhibitors, in the present study these novel cholic acid derivatives induced host cell fusion during the progress of HIV-1 infection and produced multinucleated giant cells. This is the first report of syncytia induction and enhancement of viral replication in HIV-1 infected T cells by cholic acid derivatives.

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Amino functionalized novel cholic acid derivatives induce HIV-1 replication and syncytia formation in T cells

Abstract

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