Amino functionalized novel cholic acid derivatives induce HIV-1 replication and syncytia formation in T cells

Deepak B. Salunke, Dyavar S. Ravi, Vandana S. Pore, Debashis Mitra, Braja G. Hazra

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Synthesis of C-11 azido/amino functionalized cholic acid derivatives has been achieved in excellent yields. Contrary to the previous prediction of analogous compounds to be HIV-1 protease inhibitors, in the present study these novel cholic acid derivatives induced host cell fusion during the progress of HIV-1 infection and produced multinucleated giant cells. This is the first report of syncytia induction and enhancement of viral replication in HIV-1 infected T cells by cholic acid derivatives.

Original languageEnglish (US)
Pages (from-to)2652-2655
Number of pages4
JournalJournal of Medicinal Chemistry
Volume49
Issue number8
DOIs
StatePublished - Apr 20 2006

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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