Amphetamine selectively enhances avoidance responding to a less salient stimulus in rats

Ming Li, Wei He, Rebecca Munro

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

This preclinical study examined the psychological processes affected by amphetamine that contribute to human psychosis. Using a novel avoidance conditioning paradigm involving two conditioned stimuli (CS) with varied salience, we found that acute amphetamine (1.5 mg/kg, i.p.) selectively enhanced avoidance responding to a less salient stimulus, but not to a salient one. These findings suggest that elevated dopaminergic activity selectively enhances the attributions of motivational salience to a less salient stimulus, a process that may bear relevance to the development of human delusional thoughts.

Original languageEnglish (US)
Pages (from-to)773-776
Number of pages4
JournalJournal of Neural Transmission
Volume115
Issue number5
DOIs
StatePublished - May 1 2008

Keywords

  • Amphetamine
  • Avoidance conditioning
  • Incentive salience
  • Rat

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

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