Amplification of the c-myc oncogene in human plasma-cell leukemia

J. Sumegi, T. Hedberg, M. Bjorkholm, T. Godal, H. Mellstedt, M. G. Nilsson, C. Perlman, G. Klein

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


We have examined primary leukemia cells from multiple myeloma and plasma-cell leukemia patients for rearrangement, amplification and expression of c-myc oncogene. No rearrangement or detectable amplification of the c-myc could be found in 21 cases of multiple myeloma. In contrast, 2/3 cases of plasma-cell leukemia showed amplification of the oncogene with concomitant higher level of expression.

Original languageEnglish (US)
Pages (from-to)367-371
Number of pages5
JournalInternational Journal of Cancer
Issue number3
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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