Amplification of the c-myc oncogene in human plasma-cell leukemia

J. Sumegi; T. Hedberg; M. Bjorkholm; T. Godal; H. Mellstedt; M. G. Nilsson; C. Perlman; G. Klein

doi:10.1002/ijc.1985.36.3.367

Amplification of the c-myc oncogene in human plasma-cell leukemia

J. Sumegi, T. Hedberg, M. Bjorkholm, T. Godal, H. Mellstedt, M. G. Nilsson, C. Perlman, G. Klein

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

We have examined primary leukemia cells from multiple myeloma and plasma-cell leukemia patients for rearrangement, amplification and expression of c-myc oncogene. No rearrangement or detectable amplification of the c-myc could be found in 21 cases of multiple myeloma. In contrast, 2/3 cases of plasma-cell leukemia showed amplification of the oncogene with concomitant higher level of expression.

Original language	English (US)
Pages (from-to)	367-371
Number of pages	5
Journal	International Journal of Cancer
Volume	36
Issue number	3
DOIs	https://doi.org/10.1002/ijc.1985.36.3.367
State	Published - 1985
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

Access to Document

10.1002/ijc.1985.36.3.367

Cite this

@article{2c3ff458509d4df497de30a6364dcf37,

title = "Amplification of the c-myc oncogene in human plasma-cell leukemia",

abstract = "We have examined primary leukemia cells from multiple myeloma and plasma-cell leukemia patients for rearrangement, amplification and expression of c-myc oncogene. No rearrangement or detectable amplification of the c-myc could be found in 21 cases of multiple myeloma. In contrast, 2/3 cases of plasma-cell leukemia showed amplification of the oncogene with concomitant higher level of expression.",

author = "J. Sumegi and T. Hedberg and M. Bjorkholm and T. Godal and H. Mellstedt and Nilsson, {M. G.} and C. Perlman and G. Klein",

year = "1985",

doi = "10.1002/ijc.1985.36.3.367",

language = "English (US)",

volume = "36",

pages = "367--371",

journal = "International Journal of Cancer",

issn = "0020-7136",

publisher = "John Wiley and Sons Inc.",

number = "3",

}

TY - JOUR

T1 - Amplification of the c-myc oncogene in human plasma-cell leukemia

AU - Sumegi, J.

AU - Hedberg, T.

AU - Bjorkholm, M.

AU - Godal, T.

AU - Mellstedt, H.

AU - Nilsson, M. G.

AU - Perlman, C.

AU - Klein, G.

PY - 1985

Y1 - 1985

N2 - We have examined primary leukemia cells from multiple myeloma and plasma-cell leukemia patients for rearrangement, amplification and expression of c-myc oncogene. No rearrangement or detectable amplification of the c-myc could be found in 21 cases of multiple myeloma. In contrast, 2/3 cases of plasma-cell leukemia showed amplification of the oncogene with concomitant higher level of expression.

AB - We have examined primary leukemia cells from multiple myeloma and plasma-cell leukemia patients for rearrangement, amplification and expression of c-myc oncogene. No rearrangement or detectable amplification of the c-myc could be found in 21 cases of multiple myeloma. In contrast, 2/3 cases of plasma-cell leukemia showed amplification of the oncogene with concomitant higher level of expression.

UR - http://www.scopus.com/inward/record.url?scp=0022205298&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022205298&partnerID=8YFLogxK

U2 - 10.1002/ijc.1985.36.3.367

DO - 10.1002/ijc.1985.36.3.367

M3 - Article

C2 - 2863225

AN - SCOPUS:0022205298

SN - 0020-7136

VL - 36

SP - 367

EP - 371

JO - International Journal of Cancer

JF - International Journal of Cancer

IS - 3

ER -

Amplification of the c-myc oncogene in human plasma-cell leukemia

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this