@article{42c61cd76a6c409db0e50e464bbe283e,
title = "Amygdala-cingulate intrinsic connectivity is associated with degree of social inhibition",
abstract = "The tendency to approach or avoid novel people is a fundamental human behavior and is a core dimension of social anxiety. Resting state fMRI was used to test for an association between social inhibition and intrinsic connectivity in 40 young adults ranging from low to high in social inhibition. Higher levels of social inhibition were associated with specific patterns of reduced amygdala-cingulate cortex connectivity. Connectivity was reduced between the superficial amygdala and the rostral cingulate cortex and between the centromedial amygdala and the dorsal anterior cingulate cortex. Social inhibition also modulated connectivity in several well-established intrinsic networks; higher social inhibition correlated with reduced connectivity with default mode and dorsal attention networks and enhanced connectivity in salience and executive control networks. These findings provide important preliminary evidence that social inhibition reflects differences in the underlying intrinsic connectivity of the brain in the absence of social stimuli or stressors.",
keywords = "Anxiety, FMRI, Inhibited temperament, Prefrontal cortex, Resting state, Social anxiety disorder",
author = "Blackford, {Jennifer Urbano} and Clauss, {Jacqueline A.} and Avery, {Suzanne N.} and Cowan, {Ronald L.} and Benningfield, {Margaret M.} and VanDerKlok, {Ross M.}",
note = "Funding Information: Research reported in this publication was supported in part by funding from the National Institute of Mental Health (MH083052 to J.U.B.; MH097344 to J.A.C.; MH102008 to S.N.A.; MH073800 to R.L.C.; and MH018921), the National Institute of Drug Abuse (DA015137, DA020149 to R.L.C. and DA000357 to American Academy of Child and Adolescent Psychiatry supporting MMB), and the Vanderbilt Institute for Clinical and Translational Research (RR024975; RR024978), the Vanderbilt Medical Scientist Training Program (National Institute of General Medical Studies; GM07347); and the Vanderbilt University Institute of Imaging Science. Within the past 3 years, Dr. Cowan has received publication royalties from Lippincott Williams and Wilkins, consultant income from the Southwest Michigan First Life Science Fund and the University of West Alabama, and research and salary support from Shire Pharmaceuticals and Novo Nordisk for projects not overlapping with this report. The other authors have no financial relationships relevant to this article. Portions of this work were presented at the American College of Neuropsychopharmacology annual meeting, Hollywood, FL, December 2012. ",
year = "2014",
month = may,
doi = "10.1016/j.biopsycho.2014.02.003",
language = "English (US)",
volume = "99",
pages = "15--25",
journal = "Biological Psychology",
issn = "0019-493X",
publisher = "Elsevier",
number = "1",
}