Amyloid precursor-like protein 2 increases the endocytosis, instability, and turnover of the H2-Kd MHC class I molecule

Amit Tuli, Mahak Sharma, Mary M. McIlhaney, James E. Talmadge, Naava Naslavsky, Steve Caplan, Joyce C. Solheim

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

The defense against the invasion of viruses and tumors relies on the presentation of viral and tumor-derived peptides to CTL by cell surface MHC class I molecules. Previously, we showed that the ubiquitously expressed protein amyloid precursor-like protein 2 (APLP2) associates with the folded form of the MHC class I molecule Kd. In the current study, APLP2 was found to associate with folded Kd molecules following their endocytosis and to increase the amount of endocytosed Kd. In addition, increased expression of APLP2 was shown to decrease Kd surface expression and thermostability. Correspondingly, Kd thermostability and surface expression were increased by down-regulation of APLP2 expression. Overall, these data suggest that APLP2 modulates the stability and endocytosis of K d molecules.

Original languageEnglish (US)
Pages (from-to)1978-1987
Number of pages10
JournalJournal of Immunology
Volume181
Issue number3
DOIs
StatePublished - Aug 1 2008

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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