Amyloid precursor protein and amyloid precursor-like protein 2 in cancer

Poomy Pandey; Bailee Sliker; Haley L. Peters; Amit Tuli; Jonathan Herskovitz; Kaitlin Smits; Abhilasha Purohit; Rakesh K. Singh; Jixin Dong; Surinder K. Batra; Donald W. Coulter; Joyce C. Solheim

doi:10.18632/oncotarget.7103

Amyloid precursor protein and amyloid precursor-like protein 2 in cancer

Poomy Pandey, Bailee Sliker, Haley L. Peters, Amit Tuli, Jonathan Herskovitz, Kaitlin Smits, Abhilasha Purohit, Rakesh K. Singh, Jixin Dong, Surinder K. Batra, Donald W. Coulter, Joyce C. Solheim

Research output: Contribution to journal › Review article › peer-review

76 Scopus citations

Abstract

Amyloid precursor protein (APP) and its family members amyloid precursor-like protein 1 (APLP1) and amyloid precursor-like protein 2 (APLP2) are type 1 transmembrane glycoproteins that are highly conserved across species. The transcriptional regulation of APP and APLP2 is similar but not identical, and the cleavage of both proteins is regulated by phosphorylation. APP has been implicated in Alzheimer's disease causation, and in addition to its importance in neurology, APP is deregulated in cancer cells. APLP2 is likewise overexpressed in cancer cells, and APLP2 and APP are linked to increased tumor cell proliferation, migration, and invasion. In this present review, we discuss the unfolding account of these APP family members' roles in cancer progression and metastasis.

Original language	English (US)
Pages (from-to)	19430-19444
Number of pages	15
Journal	Oncotarget
Volume	7
Issue number	15
DOIs	https://doi.org/10.18632/oncotarget.7103
State	Published - Apr 12 2016

Keywords

Amyloid precursor protein
Amyloid precursor-like protein 2
Cancer
Growth
Migration

ASJC Scopus subject areas

Oncology

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10.18632/oncotarget.7103

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title = "Amyloid precursor protein and amyloid precursor-like protein 2 in cancer",

abstract = "Amyloid precursor protein (APP) and its family members amyloid precursor-like protein 1 (APLP1) and amyloid precursor-like protein 2 (APLP2) are type 1 transmembrane glycoproteins that are highly conserved across species. The transcriptional regulation of APP and APLP2 is similar but not identical, and the cleavage of both proteins is regulated by phosphorylation. APP has been implicated in Alzheimer's disease causation, and in addition to its importance in neurology, APP is deregulated in cancer cells. APLP2 is likewise overexpressed in cancer cells, and APLP2 and APP are linked to increased tumor cell proliferation, migration, and invasion. In this present review, we discuss the unfolding account of these APP family members' roles in cancer progression and metastasis.",

keywords = "Amyloid precursor protein, Amyloid precursor-like protein 2, Cancer, Growth, Migration",

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AU - Pandey, Poomy

AU - Sliker, Bailee

AU - Peters, Haley L.

AU - Tuli, Amit

AU - Herskovitz, Jonathan

AU - Smits, Kaitlin

AU - Purohit, Abhilasha

AU - Singh, Rakesh K.

AU - Dong, Jixin

AU - Batra, Surinder K.

AU - Coulter, Donald W.

AU - Solheim, Joyce C.

PY - 2016/4/12

Y1 - 2016/4/12

N2 - Amyloid precursor protein (APP) and its family members amyloid precursor-like protein 1 (APLP1) and amyloid precursor-like protein 2 (APLP2) are type 1 transmembrane glycoproteins that are highly conserved across species. The transcriptional regulation of APP and APLP2 is similar but not identical, and the cleavage of both proteins is regulated by phosphorylation. APP has been implicated in Alzheimer's disease causation, and in addition to its importance in neurology, APP is deregulated in cancer cells. APLP2 is likewise overexpressed in cancer cells, and APLP2 and APP are linked to increased tumor cell proliferation, migration, and invasion. In this present review, we discuss the unfolding account of these APP family members' roles in cancer progression and metastasis.

AB - Amyloid precursor protein (APP) and its family members amyloid precursor-like protein 1 (APLP1) and amyloid precursor-like protein 2 (APLP2) are type 1 transmembrane glycoproteins that are highly conserved across species. The transcriptional regulation of APP and APLP2 is similar but not identical, and the cleavage of both proteins is regulated by phosphorylation. APP has been implicated in Alzheimer's disease causation, and in addition to its importance in neurology, APP is deregulated in cancer cells. APLP2 is likewise overexpressed in cancer cells, and APLP2 and APP are linked to increased tumor cell proliferation, migration, and invasion. In this present review, we discuss the unfolding account of these APP family members' roles in cancer progression and metastasis.

KW - Amyloid precursor protein

KW - Amyloid precursor-like protein 2

KW - Cancer

KW - Growth

KW - Migration

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Amyloid precursor protein and amyloid precursor-like protein 2 in cancer

Abstract

Keywords

ASJC Scopus subject areas

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