An Animal Model for the Study of Small-Bowel Tumors1

J. Graham Sharp, James W. Osborne

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


An animal model for the study of small-bowel tumors has been investigated. Tumors were induced in male Holtzman rats by X-irradiation of only the hypoxic, temporarily exteriorized ileum and jejunum. Following an exposure of 2000 R, 56% of the rats developed adenocarcinoma somewhere in the irradiated segment. Macroscopic metastases were not observed outside the small intestine; however, metastases or direct extensions were observed histologically in the mesentery, pancreas, and abdominal wall. An anemia associated with the intestinal tumors was investigated in detail; the erythrocytes were found to be hypochromic and macrocytic. The anemia appeared to be the result of blood loss from the tumors into the intestinal lumen. Other pathological features associated with these rat intestinal tumors were weight loss, diarrhea, obstruction of the small bowel, and intestinal perforation and hemorrhage. These features are similar to those described in the literature for malignant tumors of the small intestine in humans. This animal model, therefore, would appear to be potentially useful for studies relating to humans with small-bowel tumors.

Original languageEnglish (US)
Pages (from-to)1487-1494
Number of pages8
JournalCancer Research
Issue number6
StatePublished - Jun 1974

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


Dive into the research topics of 'An Animal Model for the Study of Small-Bowel Tumors1'. Together they form a unique fingerprint.

Cite this