An approach to sequence DNA without tagging

Sanjun Niu; Ravi F. Saraf

doi:10.1117/12.446773

An approach to sequence DNA without tagging

Research output: Contribution to journal › Conference article › peer-review

Abstract

A concept to sequence DNA without tagging the molecule is developed. The fabrication process is compatible with current microelectronics and (emerging) soft-material fabrication technologies, allowing the method to be integrable with MEMS and lab-on-a-chip devices. The preliminary results indicate sensitivity in the nano-gram regime for 100 micron-square pixels. The technology can be extended to perform combinatorial analysis with on-line measurement in real-time during the hybridization process.

Original language	English (US)
Pages (from-to)	246-254
Number of pages	9
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	4512
DOIs	https://doi.org/10.1117/12.446773
State	Published - 2001
Event	Complex Adaptive Structures - Hutchinson Island, FL, United States Duration: Jun 4 2001 → Jun 6 2001

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

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abstract = "A concept to sequence DNA without tagging the molecule is developed. The fabrication process is compatible with current microelectronics and (emerging) soft-material fabrication technologies, allowing the method to be integrable with MEMS and lab-on-a-chip devices. The preliminary results indicate sensitivity in the nano-gram regime for 100 micron-square pixels. The technology can be extended to perform combinatorial analysis with on-line measurement in real-time during the hybridization process.",

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