An EEG analysis of convulsive activity produced by cholinergic agents

Steven L. Cohen; Barbara J. Morley; O. Carter Snead

doi:10.1016/0364-7722(81)90089-8

An EEG analysis of convulsive activity produced by cholinergic agents

Steven L. Cohen, Barbara J. Morley, O. Carter Snead

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

1. 1. EEG activity was assessed in rats following the intraventricular injection of cholinergic agonists (carbamylcholine and nicotine tartrate), nicotinic antagonists (d-tubocurarine and α-bungarotoxin), ganglionic blockers (mecamylamine and hexamethonium), decamethonium, antibodies prepared against purified electric fish acetylcholine receptor, and human sera from myasthenic and epileptic patients. 2. 2. Seizures were produced only by agonists and nicotinic antagonists. 3. 3. Carbamylcholine produced clonic/tonic convulsions. Nicotine resulted in a depressed EEG with sporadic seizures. 4. 4. Both antagonists produced clonic/tonic seizures and spike activity. Carbamylcholine-induced seizures were blocked by scopolamine. 5. 5. No agent was found to block antagonist-induced seizures.

Original language	English (US)
Pages (from-to)	383-388
Number of pages	6
Journal	Progress in Neuro-Psychopharmacology
Volume	5
Issue number	4
DOIs	https://doi.org/10.1016/0364-7722(81)90089-8
State	Published - 1981
Externally published	Yes

Keywords

EEG
carbamylcholine
nicotine
nicotinic acetylcholine receptors
α-bungarotoxin

ASJC Scopus subject areas

Neuroscience(all)
Pharmacology, Toxicology and Pharmaceutics(all)
Psychiatry and Mental health
Pharmacology (medical)

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10.1016/0364-7722(81)90089-8

Cite this

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title = "An EEG analysis of convulsive activity produced by cholinergic agents",

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year = "1981",

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AU - Cohen, Steven L.

AU - Morley, Barbara J.

AU - Snead, O. Carter

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N2 - 1. 1. EEG activity was assessed in rats following the intraventricular injection of cholinergic agonists (carbamylcholine and nicotine tartrate), nicotinic antagonists (d-tubocurarine and α-bungarotoxin), ganglionic blockers (mecamylamine and hexamethonium), decamethonium, antibodies prepared against purified electric fish acetylcholine receptor, and human sera from myasthenic and epileptic patients. 2. 2. Seizures were produced only by agonists and nicotinic antagonists. 3. 3. Carbamylcholine produced clonic/tonic convulsions. Nicotine resulted in a depressed EEG with sporadic seizures. 4. 4. Both antagonists produced clonic/tonic seizures and spike activity. Carbamylcholine-induced seizures were blocked by scopolamine. 5. 5. No agent was found to block antagonist-induced seizures.

AB - 1. 1. EEG activity was assessed in rats following the intraventricular injection of cholinergic agonists (carbamylcholine and nicotine tartrate), nicotinic antagonists (d-tubocurarine and α-bungarotoxin), ganglionic blockers (mecamylamine and hexamethonium), decamethonium, antibodies prepared against purified electric fish acetylcholine receptor, and human sera from myasthenic and epileptic patients. 2. 2. Seizures were produced only by agonists and nicotinic antagonists. 3. 3. Carbamylcholine produced clonic/tonic convulsions. Nicotine resulted in a depressed EEG with sporadic seizures. 4. 4. Both antagonists produced clonic/tonic seizures and spike activity. Carbamylcholine-induced seizures were blocked by scopolamine. 5. 5. No agent was found to block antagonist-induced seizures.

KW - EEG

KW - carbamylcholine

KW - nicotine

KW - nicotinic acetylcholine receptors

KW - α-bungarotoxin

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ER -

An EEG analysis of convulsive activity produced by cholinergic agents

Abstract

Keywords

ASJC Scopus subject areas

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