An Efficient Route to N-Monosubstituted Guanidino-Lactams

Sara Tommasi, Chiara Zanato, Rey Carabeo, Arduino A. Mangoni, Sergio Dall'Angelo, Matteo Zanda

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


A small library of guanidino-lactams were synthesized in four steps and good overall yields by following the routes: preparation of guanylating agents, synthesis of protected guanidino-acids, cyclization to fully protected guanidino-lactams, and deprotection to the target compounds. The guanidino-lactams were assayed as antimicrobials on E. coli showing no significant antibiotic activity.

Original languageEnglish (US)
Article numberss-2015-n0113-op
Pages (from-to)3067-3078
Number of pages12
JournalSynthesis (Germany)
Issue number19
StatePublished - Oct 1 2015
Externally publishedYes


  • antimicrobials
  • cyclization
  • guanidines
  • guanylation
  • lactams

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry


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