An Efficient Route to N-Monosubstituted Guanidino-Lactams

Sara Tommasi; Chiara Zanato; Rey Carabeo; Arduino A. Mangoni; Sergio Dall'Angelo; Matteo Zanda

doi:10.1055/s-0034-1378845

An Efficient Route to N-Monosubstituted Guanidino-Lactams

Sara Tommasi, Chiara Zanato, Rey Carabeo, Arduino A. Mangoni, Sergio Dall'Angelo, Matteo Zanda

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

A small library of guanidino-lactams were synthesized in four steps and good overall yields by following the routes: preparation of guanylating agents, synthesis of protected guanidino-acids, cyclization to fully protected guanidino-lactams, and deprotection to the target compounds. The guanidino-lactams were assayed as antimicrobials on E. coli showing no significant antibiotic activity.

Original language	English (US)
Article number	ss-2015-n0113-op
Pages (from-to)	3067-3078
Number of pages	12
Journal	Synthesis (Germany)
Volume	47
Issue number	19
DOIs	https://doi.org/10.1055/s-0034-1378845
State	Published - Oct 1 2015
Externally published	Yes

Keywords

antimicrobials
cyclization
guanidines
guanylation
lactams

ASJC Scopus subject areas

Catalysis
Organic Chemistry

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10.1055/s-0034-1378845

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title = "An Efficient Route to N-Monosubstituted Guanidino-Lactams",

abstract = "A small library of guanidino-lactams were synthesized in four steps and good overall yields by following the routes: preparation of guanylating agents, synthesis of protected guanidino-acids, cyclization to fully protected guanidino-lactams, and deprotection to the target compounds. The guanidino-lactams were assayed as antimicrobials on E. coli showing no significant antibiotic activity.",

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AU - Tommasi, Sara

AU - Zanato, Chiara

AU - Carabeo, Rey

AU - Mangoni, Arduino A.

AU - Dall'Angelo, Sergio

AU - Zanda, Matteo

N1 - Publisher Copyright: © Georg Thieme Verlag Stuttgart New York.

PY - 2015/10/1

Y1 - 2015/10/1

N2 - A small library of guanidino-lactams were synthesized in four steps and good overall yields by following the routes: preparation of guanylating agents, synthesis of protected guanidino-acids, cyclization to fully protected guanidino-lactams, and deprotection to the target compounds. The guanidino-lactams were assayed as antimicrobials on E. coli showing no significant antibiotic activity.

AB - A small library of guanidino-lactams were synthesized in four steps and good overall yields by following the routes: preparation of guanylating agents, synthesis of protected guanidino-acids, cyclization to fully protected guanidino-lactams, and deprotection to the target compounds. The guanidino-lactams were assayed as antimicrobials on E. coli showing no significant antibiotic activity.

KW - antimicrobials

KW - cyclization

KW - guanidines

KW - guanylation

KW - lactams

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An Efficient Route to N-Monosubstituted Guanidino-Lactams

Abstract

Keywords

ASJC Scopus subject areas

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