An epitope from Acanthamoeba castellanii that cross-react with proteolipid protein 139-151-reactive T cells induces autoimmune encephalomyelitis in SJL mice

Chandirasegaran Massilamany, David Steffen, Jay Reddy

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

We report here that an epitope (aa, 83-95) derived from Acanthamoeba castellanii (ACA) induces clinical signs of experimental autoimmune encephalomyelitis (EAE) in SJL/J mice reminiscent of the disease induced with myelin proteolipid protein (PLP) 139-151. By using IAs/tetramers, we demonstrate that both ACA 83-95 and PLP 139-151 generate antigen-specific cross-reactive CD4 T cells and the T cells secrete identical patterns of cytokines and induce EAE with a similar severity. These results may provide insights into the pathogenesis of multiple sclerosis and ACA-induced granulomatous encephalitis.

Original languageEnglish (US)
Pages (from-to)17-24
Number of pages8
JournalJournal of Neuroimmunology
Volume219
Issue number1-2
DOIs
StatePublished - Feb 1 2010

Keywords

  • Acanthamoeba castellanii
  • Acanthamoeba granulomatous encephalitis
  • Experimental autoimmune encephalomyelitis
  • Molecular mimicry
  • Multiple sclerosis
  • Proteolipid protein

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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