An essential role for Daxx in the inhibition of B lymphopoiesis by type I interferons

Rafael Gongora, Robert P. Stephan, Zhixin Zhang, Max D. Cooper

Research output: Contribution to journalArticlepeer-review

89 Scopus citations

Abstract

Interferon-α and -β inhibit the interleukin-7-mediated growth and survival of T and B lymphoid progenitors via an unknown, STAT1-independent pathway. Gene expression profile analysis of interferon-β-treated progenitor B cells revealed enhanced Daxx expression, with concomitant Daxx protein increase and nuclear body translocation. The interferon effects included downregulation of cell cycle regulating genes and cell cycle arrest, followed by Bcl-2 downregulation and apoptosis. Daxx antisense oligonucleotides rescued the interferon-treated pro-B cells from growth arrest and apoptosis in parallel with the reduction of nuclear Daxx. These findings implicate the gene repressor function of Daxx in interferon-induced apoptosis of lymphoid progenitors.

Original languageEnglish (US)
Pages (from-to)727-737
Number of pages11
JournalImmunity
Volume14
Issue number6
DOIs
StatePublished - 2001
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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