An evolutionarily conserved protein fraction stably linked to DNA

Zoya Avramova, Ivailo Mikhailov, Roumen Tsanev

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Chromatins from four evolutionarily remote species (insect, fish, amphibian and bird) were isolated, high-salt-extracted and extensively deproteinized to remove noncovalently associated proteins. A protein fraction resisting the extraction procedures was found firmly linked to DNA in all four chromatins. Two-dimensional tryptic peptide mapping revealed a remarkable evolutionary conservativeness of this protein component, suggesting an indispensable function for it in the nucleus.

Original languageEnglish (US)
Pages (from-to)109-111
Number of pages3
JournalBBA - Gene Structure and Expression
Issue number1
StatePublished - Jan 13 1989
Externally publishedYes


  • Chromatin
  • DNA-protein interaction
  • Evolution

ASJC Scopus subject areas

  • Structural Biology
  • Biophysics
  • Biochemistry
  • Genetics


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