Chromatins from four evolutionarily remote species (insect, fish, amphibian and bird) were isolated, high-salt-extracted and extensively deproteinized to remove noncovalently associated proteins. A protein fraction resisting the extraction procedures was found firmly linked to DNA in all four chromatins. Two-dimensional tryptic peptide mapping revealed a remarkable evolutionary conservativeness of this protein component, suggesting an indispensable function for it in the nucleus.
|Original language||English (US)|
|Number of pages||3|
|Journal||BBA - Gene Structure and Expression|
|State||Published - Jan 13 1989|
- DNA-protein interaction
ASJC Scopus subject areas
- Structural Biology